AI Article Synopsis
- L-fucose, a type of deoxyhexose sugar, plays a critical role in biological processes in humans and their gut microbiota.
- It is found in high amounts on gut mucosal surfaces, microbial structures, and some foods, helping establish a healthy microbiota and offering protection against infections.
- However, some pathogens can use these fucosylated structures to cause disease, and a lack of proper fucosylation in the host is linked to various health issues, highlighting its importance in host-microbe interactions in the gastrointestinal tract.
Article Abstract
The deoxyhexose sugar L-fucose is important for many biological processes within the human body and the associated microbiota. This carbohydrate is abundant in host gut mucosal surfaces, numerous microbial cell surface structures, and some dietary carbohydrates. Fucosylated oligosaccharides facilitate the establishment of a healthy microbiota and provide protection from infection. However, there are instances where pathogens can also exploit these fucosylated structures to cause infection. Furthermore, deficiencies in host fucosylation are associated with specific disease outcomes. This review focuses on our current understanding of the impact of fucosylation within the mucosal environment of the gastrointestinal tract with a specific emphasis on the mediatory effects in host-microbe interactions.
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| http://dx.doi.org/10.1111/mmi.14681 | DOI Listing |
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