Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Infection.

J Immunol

Center for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, LA 70112;

Published: February 2021

Type 17 cytokines have been strongly implicated in mucosal immunity, in part by regulating the production of antimicrobial peptides. Using a mouse model of infection, which causes colitis, we found that intestinal IL-17RA and IL-17RC were partially required for control of infection in the colon and IL-17 regulates the production of luminal hydrogen peroxide as well as expression of Reduced expression was associated with a profound defect in generating -specific IgA Ab-secreting cells. Taken together, intestinal IL-17R signaling plays key roles in controlling invading pathogens, in part by regulating luminal hydrogen peroxide as well as regulating the generation of pathogen-specific IgA Ab-secreting cells.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663204PMC
http://dx.doi.org/10.4049/jimmunol.2000591DOI Listing

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