AI Article Synopsis
- Living organisms vary in size by over 20 orders of magnitude, which can challenge researchers studying growth mechanisms.
- Recent studies suggest that there are common principles of growth applicable to diverse organisms like fruit flies, mice, and humans.
- The research integrates developmental biology, physics, and evolutionary biology while shedding light on important medical issues like tissue regeneration, metabolic homeostasis, and cancer.
Article Abstract
The sizes of living organisms span over 20 orders of magnitude or so. This daunting observation could intimidate researchers aiming to understand the general mechanisms controlling growth. However, recent progress suggests the existence of principles common to organisms as diverse as fruit flies, mice and humans. As we review here, these studies have provided insights into both autonomous and non-autonomous mechanisms controlling organ growth as well as some of the principles underlying growth coordination between organs and across bilaterally symmetrical organisms. This research tackles several aspects of developmental biology and integrates inputs from physics, mathematical modelling and evolutionary biology. Although many open questions remain, this work also helps to shed light on medically related conditions such as tissue and limb regeneration, as well as metabolic homeostasis and cancer.
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| http://dx.doi.org/10.1242/dev.196063 | DOI Listing |
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