The study aimed to explore the cortical thickness and gyrification abnormalities in acute brainstem ischemic patients in both the ipsilateral and contralateral hemisphere compared with healthy controls. Structural magnetic resonance imaging data were prospectively acquired in 48 acute brainstem ischemic patients, 21 patients with left lesion and 27 with right lesion, respectively. Thirty healthy controls were recruited. Cortical morphometry based on surface-based data analysis driven by CAT12 toolbox implemented in SPM12 was used to compare changes in cortical thickness and gyrification. Significant decreases of cortical thickness loss were found in bilateral cerebral hemispheres of the brainstem ischemic patients compared to the healthy controls (P < .05, family-wise error (FWE)-corrected). We also found significant gyrification decreases in the insula, transverse temporal, supramarginal of the ipsilateral on hemisphere in the right brainstem ischemic patients compared to the healthy controls (P < .05, FWE-corrected). Brainstem ischemic patients have widely morphological changes in the early phase and may be helpful in designing individualized rehabilitative strategies for these patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793415 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000024262 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sodium ferulate attenuates ischaemic stroke by mediating the upregulation of thrombospondin-4 expression and combined treatment with bone marrow mesenchymal stem cells.
Exp Neurol
December 2024
Department of Encephalopathy, Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong 518000, China; Department of Encephalopathy, Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine, Shenzhen, Guangdong 518000, China. Electronic address:
Ischaemic stroke is one of the major diseases affecting human health, involving complex and diverse pathological mechanisms, including inflammatory response, oxidative stress and angiogenesis. Sodium ferulate (SF) exerts a protective effect on cerebral ischaemia/reperfusion and when combined with bone marrow mesenchymal stem cells (BMSCs), has a considerable therapeutic effect on brain injury in rats. Here, we speculate that SF also exerts cerebroprotective effects.
View Article and Find Full Text PDFDorsolateral pontine lesions produce distinct ocular motor abnormalities with anatomical correlations.
Eur J Neurol
January 2025
Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Background And Purpose: The dorsolateral portion of the caudal pons contains the vestibular nucleus (VN) and inferior cerebellar peduncle (ICP) that play important roles in conveying and processing vestibular and ocular motor signals. This study aimed to characterize ocular motor abnormalities along with their anatomical correlations in dorsolateral pons (DLP) lesions.
Methods: We analyzed clinical features, and results of neuro-otological evaluations and neuroimaging of 18 patients with unilateral DLP lesions (17 with DLP infarction and 1 with cavernous malformation) from among 506 patients with pontine infarction in a stroke registry.
Natural history of dolichoectatic vertebrobasilar aneurysms: a multinational study.
J Neurosurg
December 2024
Departments of1Neurosurgery and.
Objective: Dolichoectatic vertebrobasilar aneurysms (DVBAs) are expansions of arterial tissue leading to aneurysmal formations without an obvious neck. Their natural history is poorly understood; usually patients are admitted with thromboembolic complications and/or neurological symptoms from the mass effect. There have not been international collective data, and correct timing for highly risky treatments has been under discussion.
View Article and Find Full Text PDFBeyond the Stroke: A Case Report of Multiple Sclerosis.
Cureus
November 2024
Department of Anaesthetics and Intensive Treatment Unit (ITU), Birmingham Heartlands Hospital, Birmingham, GBR.
Multiple sclerosis is an inflammatory, autoimmune demyelinating condition and poses diagnostic challenges due to varied presentations. This case report presents a divergence from typical clinical presentations of multiple sclerosis (MS), as the initial presentation resembled symptoms of a brain stem stroke. Conventionally, MS suspicion arises in the presence of previous neurological deficits or signs of optic neuritis.
View Article and Find Full Text PDF[Effects of Qixiong Zuogui Compound Prescription on blood-brain barrier permeability of rats with ischemic stroke by interfering in exosomes of bone marrow stem cells and its anti-aging effects].
Zhongguo Zhong Yao Za Zhi
September 2024
the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
This study explores the reparative effect of Qixiong Zuogui Compound Prescription(QXZG) intervention on the blood-brain barrier(BBB) in the aging brain with middle cerebral artery occlusion(MCAO) in rats mediated by bone marrow stem cells(BMSCs)-derived exosomes, as well as its anti-aging mechanism. An aging MCAO composite model was established using D-galactose-induced aging combined with line embolism. Rats were divided into young sham surgery group, aging sham surgery group, model group, exosome group, and exosome with traditional Chinese medicine(TCM) intervention group.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!