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Effects of gamma ionizing radiation exposure on Danio rerio embryo-larval stages - comparison with tritium exposure. | LitMetric

Effects of gamma ionizing radiation exposure on Danio rerio embryo-larval stages - comparison with tritium exposure.

J Hazard Mater

Institut de Radioprotection et de Sureté Nucléaire (IRSN), PSE-SANTE/SDOS/LMDN, Cadarache, Saint-Paul-lez-Durance 13115, France.

Published: April 2021

AI Article Synopsis

  • The study aimed to analyze how ionizing radiation affects zebrafish during early development by looking at both molecular and phenotypic changes.
  • Zebrafish larvae, aged 3 hours post-fertilization, were exposed to gamma radiation at varying levels, including doses above the protective benchmark for ecosystems.
  • Results indicated that while survival and hatching rates remained unaffected, there was increased production of reactive oxygen species (ROS) and muscle damage across all radiation doses, aligning with previous findings on beta radiation (tritium) exposure.

Article Abstract

The objective was to investigate the effects of ionizing radiation induced in zebrafish early life stages by coupling responses obtained at the molecular (genotoxicity, ROS production, gene expression) and phenotypic (tissue alteration, embryo-larval development) levels. Here we present results obtained after exposure of 3 hpf larvae to 10 days of gamma irradiation at 3.3 × 10, 1.3 × 10 and 1.2 × 10 µGy/h, close to and higher than the benchmark for protection of ecosystems towards ionizing radiations of 10 µGy/h. Dose rates used in these studies were chosen to be in the 'derived consideration reference level' (DCRL) for gamma irradiation where deleterious effects can appear in freshwater fish. Also, these dose rates were similar to the ones already tested on tritium (beta ionizing radiation) in our previous work, in order to compare both types of ionizing radiation. Results showed that gamma irradiation did not induce any effect on survival and hatching. No effect was observed on DNA damages, but ROS production was increased. Muscle damages were observed for all tested dose rates, similarly to previous results obtained with tritium (beta ionizing radiation) at similar dose rates. Some molecular responses therefore appeared to be relevant for the study of gamma ionizing radiation effects in zebrafish.

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Source
http://dx.doi.org/10.1016/j.jhazmat.2020.124866DOI Listing

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