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Individual differences in intolerance of uncertainty is primarily linked to the structure of inferior frontal regions.
Cogn Affect Behav Neurosci
January 2025
Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA.
Increased intolerance of uncertainty (IU), or distress felt when encountering situations with unknown outcomes, occurs transdiagnostically across various forms of psychopathology and is targeted in therapeutic intervention. Increased intolerance of uncertainty shows overlap with symptoms of internalizing disorders, such as depression and anxiety, including negative affect and anxious apprehension (worry). While neuroanatomical correlates of IU have been reported, previous investigations have not disentangled the specific neural substrates of IU above and beyond any overlapping relationships with aspects of internalizing psychopathology.
View Article and Find Full Text PDFEffectiveness of Poverty Reduction Programs on Psychological Development of Children and Adolescents at Risk of Poverty: A Systematic Review and Meta-analysis.
J Youth Adolesc
January 2025
Department of Social Work, the Chinese University of Hong Kong, Hong Kong, China.
Considering the potential detrimental impact of poverty on psychological development and the resulting harmful cycles, implementing poverty alleviation interventions is necessary for children and adolescents. Although several meta-analyses have demonstrated the effectiveness of monetary poverty reduction programs, there remains a significant gap in understanding how multidimensional poverty reduction strategies boost psychological development. This meta-analysis aims to address this gap by disclosing the impact of multifaceted anti-poverty interventions on the psychological development of children and adolescents.
View Article and Find Full Text PDFChinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial.
BMJ Open
January 2025
Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
Objectives: To assess the therapeutic effects and safety of Tongxie Yaofang (TXYF) granules vs placebo as an alternative treatment for diarrhoea-predominant irritable bowel syndrome (IBS-D). We hypothesised that TXYF would improve clinical responses among patients with IBS-D.
Design: A randomised, double-blind, placebo-controlled, phase II, superiority trial.
Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece).
J Dermatolog Treat
December 2025
2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Attikon" University General Hospital, Athens, Greece.
Objective: To characterize the systemic treatment patterns and current state of moderate-to-severe psoriasis patients in real-world settings in Greece.
Methods: CRYSTAL-Greece was a multicenter, cross-sectional and retrospective chart review study assessing Psoriasis Area and Index (PASI), Dermatology Life Quality Index (DLQI) and EuroQol-5-Dimensions 5-Levels (EQ-5D-5L). Eligible patients were consented adults (18-75 years old) on continuous treatment with any approved systemic therapy regimen for ≥24 weeks.
The effect of maternal risk factors during pregnancy on children's motor development at 5-6 years.
Clin Nutr ESPEN
January 2025
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20520 Turku, Finland; Nutrition and Food Research Center, University of Turku, 20014 Turku, Finland.
Background And Aims: Maternal diet and health may influence a child's later neurodevelopment. We investigated the effect of maternal diet, adiposity, gestational diabetes mellitus (GDM), and depressive/anxiety symptoms during pregnancy on the child's motor outcome at 5-6 years.
Methods: The motor performance of 159 children of women with overweight or obesity (pre-pregnancy body mass index 25-29.
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