AI Article Synopsis
- Environmental factors like temperature impact neuronal activity and development, but their effects on synaptic subcellular specificity are not fully understood.
- Using the nematode C. elegans AIY interneurons, researchers found that high temperatures can cause defects in synaptic specificity through glutamatergic neurotransmission.
- The study identified that glutamate is primarily released by ASH sensory neurons and detected by specific inhibitory channels (GLC-3 and GLC-4) in AIY, offering new insights into how temperature affects neuronal function.
Article Abstract
Environmental factors such as temperature affect neuronal activity and development. However, it remains unknown whether and how they affect synaptic subcellular specificity. Here, using the nematode Caenorhabditis elegans AIY interneurons as a model, we found that high cultivation temperature robustly induces defects in synaptic subcellular specificity through glutamatergic neurotransmission. Furthermore, we determined that the functional glutamate is mainly released by the ASH sensory neurons and sensed by two conserved inhibitory glutamate-gated chloride channels GLC-3 and GLC-4 in AIY. Our work not only presents a novel neurotransmission-dependent mechanism underlying the synaptic subcellular specificity, but also provides a potential mechanistic insight into high-temperature-induced neurological defects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822552 | PMC |
| http://dx.doi.org/10.1371/journal.pgen.1009295 | DOI Listing |
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