Introduction: We determine whether diminished Learning Over Repeated Exposures (LORE) identifies subtle memory decrements in cognitively unimpaired (CU) older adults with Alzheimer's disease (AD) biomarker burden.
Methods: Ninety-four CU participants (mean age = 77.6 ± 5.02) completed a challenging associative memory test, at home, monthly, for up to 1 year (mean = 9.97 months) on a study-issued iPad. Learning curves for face-name memory were computed for two versions completed monthly: same face-name pairs (A-A-A) and alternate face-name pairs (B-C-D). Positron emission tomography (PET) imaging characterized global amyloid (Pittsburgh Compound-B (PiB); amyloid beta (Aβ)+/-) and regional tau burden (flortaucipir).
Results: Diminished LORE for same (but not alternate) face-name pairs was associated with greater amyloid and tau burden. Aβ+/- group differences for same face-name pairs emerged by the fourth exposure and was of medium-to-large magnitude (Cohen's d = 0.66; 95% confidence interval [CI] = 0.25-1.08).
Discussion: Subtle decrements in learning related to AD pathological burden in CU are detectable over short time-intervals (ie, months). Implications for prevention trial design are discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784542 | PMC |
| http://dx.doi.org/10.1002/dad2.12132 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Face masks degrade our ability to remember face-name associations more than predicted by judgments of learning.
Memory
February 2024
Department of Psychology, University of Tampa, Tampa, USA.
In response to the COVID-19 pandemic, face masks became required attire. Face masks obstruct the bottom portion of faces, restricting face processing. The present study examined the influence face masks have on memory predictions and memory performance for new face-name associations.
View Article and Find Full Text PDFCircadian- and wake-dependent influences on face-name memory in healthy men and women over 3weeks of chronic sleep restriction.
Sleep Health
February 2024
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Objectives: Facial recognition is one of the key functions of the human brain, and linking a face to a name is critical in many social and occupational settings. This study assessed circadian- and wake-dependent effects on face-name recognition in healthy adults.
Methods: Thirteen healthy adults (20-70years; 7 F) were studied in a 39-day inpatient protocol that included 3weeks of 28 hours forced desynchrony with sleep restriction (6.
A novel face-name mnemonic discrimination task with naturalistic stimuli.
Neuropsychologia
October 2023
Psychological Sciences, Rice University, 6500 Main St, Houston, TX, 77030, USA. Electronic address:
Difficulty remembering faces and names is a common struggle for many people and gets more difficult as we age. Subtle changes in appearance from day to day, common facial characteristics across individuals, and overlap of names may contribute to the difficulty of learning face-name associations. Computational models suggest the hippocampus plays a key role in reducing interference across experiences with overlapping information by performing pattern separation, which enables us to encode similar experiences as distinct from one another.
View Article and Find Full Text PDFPerilesional and contralesional brain activations related to associative encoding of unfamiliar face-names pairs in adults with left chronic stroke with or without ischemic infarct on left inferior frontal gyrus.
Cortex
November 2023
Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Neuroimagem Funcional (NIF) - Laboratory of Medical Investigations on Magnetic Resonance Imaging (LIM-44), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
The study of an Ischemic stroke infarction allows verifying how the lesion produces alterations in the neuronal networks resulting in cognitive deficits. It also allows the verification of adaptive and maladaptive cerebral reorganization related to the injury. In our previous fMRI study, we found that patients without ischemic vascular lesions in left inferior frontal gyrus showed an efficient compensation mechanism during the associative encoding of face name pairs, by the increased activation of ventrolateral and dorsolateral areas of contralesional hemisphere associated with better memory performance.
View Article and Find Full Text PDFIntersubject similarity in neural representations underlies shared episodic memory content.
Proc Natl Acad Sci U S A
August 2023
State Key Laboratory of Cognitive Neuroscience and Learning and International Data Group/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Individuals generally form their unique memories from shared experiences, yet the neural representational mechanisms underlying this subjectiveness of memory are poorly understood. The current study addressed this important question from the cross-subject neural representational perspective, leveraging a large functional magnetic resonance imaging dataset ( = 415) of a face-name associative memory task. We found that individuals' memory abilities were predicted by their synchronization to the group-averaged, canonical trial-by-trial activation level and, to a lesser degree, by their similarity to the group-averaged representational patterns during encoding.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!