The legal system and the laboratory are becoming involved with each other on a daily basis today and the technologist is, willingly or unwillingly, being drawn into this unfamiliar arena. This article will explain some of the manner by which a part of that arena operates, specifically the trial courts. Whether civil or criminal, these courts are governed by rules and methods of operation for the persons in them. In the case of the laboratorian, the role is that of witness, and this article attempts to dispel any fears of that role and teaches how to best prepare for it.
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Neurogenetics
January 2025
Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
The cytoskeleton, composed of microtubules, intermediate filaments and actin filaments is vital for various cellular functions, particularly within the nervous system, where microtubules play a key role in intracellular transport, cell morphology, and synaptic plasticity. Tubulin-specific chaperones, including tubulin folding cofactors (TBCA, TBCB, TBCC, TBCD, TBCE), assist in the proper formation of α/β-tubulin heterodimers, essential for microtubule stability. Pathogenic variants in these chaperone-encoding genes, especially TBCD, have been linked to Progressive Encephalopathy with Brain Atrophy and Thin Corpus Callosum (PEBAT, OMIM #604,649), a severe neurodevelopmental disorder.
View Article and Find Full Text PDFInt J Legal Med
January 2025
Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
China's forensic pathology standardization has accumulated more than 30 years of experience, but there is limited research summarizing the features and detailed information concerning these standards. In this paper, we collected documents on forensic pathology standards and statistically analyzed their types, effective scopes, drafting units, authorization departments, promulgation times, revision cycles, and other information. All of the standards information was obtained from standardization websites and databases.
View Article and Find Full Text PDFFront Sports Act Living
January 2025
Shanghai Normal University, Sport Department, Shanghai, China.
The rapid development of prepaid consumption in China's sports industry has been hindered by fundamental issues such as operators' blind expansion, lack of transparency in business information, absence of standard contract texts, and inadequate consumer rights protection. These challenges have led to business closures, unfair contract terms, difficulties in card refunds and transfers, and the excessive issuance of long-term or lifetime prepaid cards. These problems severely damage the industry's integrity and impede its healthy and sustainable development.
View Article and Find Full Text PDFCureus
December 2024
Department of Clinical and Forensic Neuroscience, University of Veracruz, Boca del Río, MEX.
Temporal lobe epilepsy (TLE) represents a prevalent form of focal epilepsy that often requires surgical intervention and can be resistant to antiseizure medications. Its epidemiology varies across regions due to diagnostic challenges and underestimation of individual neurological traits. Despite these complexities, TLE accounts for a significant proportion of total epilepsies worldwide.
View Article and Find Full Text PDFItal J Pediatr
January 2025
Child Healthcare Department, Children's Hospital of Nanjing Medical University, Jiangdong South No.8 Road, Nanjing, Jiangsu, 210008, China.
Background: This study aimed to investigate deoxyribonucleic acid (DNA) copy number variations (CNVs) in children with neurodevelopmental disorders and their association with craniofacial abnormalities.
Methods: A total of 1,457 children who visited the Child Health Department of our hospital for unexplained Neurodevelopmental disorders (NDDs) between November 2019 and December 2022 were enrolled. Peripheral venous blood samples (2 mL) were collected from the children and their parents for whole-exome sequencing.
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