Ever since endogenous hydrogen sulfide (HS) was found in mammals in 1989, accumulated evidence has demonstrated that HS functions as a novel neurological gasotransmitter in brain tissues and may play a key role in traumatic brain injury. It has been proved that HS has an antioxidant, anti-inflammatory, and antiapoptosis function in the neuron system and functions as a neuroprotective factor against secondary brain injury. In addition, HS has other biologic effects such as regulating the intracellular concentration of Ca, facilitating hippocampal long-term potentiation (LTP), and activating ATP-sensitive K channels. Due to the toxic nature of HS when exceeding the physiological dose in the human body, only a small amount of HS-related therapies was applied to clinical treatment. Therefore, it has huge therapeutic potential and has great hope for recovering patients with traumatic brain injury.
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| http://dx.doi.org/10.1155/2020/7301615 | DOI Listing |
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