AI Article Synopsis
- MS is a common neuroimmunological disease affecting young adults, with women of childbearing age being at risk of unplanned pregnancies and the complexities of polypharmacy due to multiple medications.
- The study analyzed data from 131 female MS patients, revealing that 41.2% were engaged in polypharmacy, which correlated with older age, higher disability, and other health issues.
- A total of 1,033 potential drug-drug interactions (DDIs) were identified, with clinically significant interactions more common in those on multiple medications, highlighting the importance of regular monitoring for these interactions to prevent adverse effects.
Article Abstract
Background And Aims: Multiple sclerosis (MS) is the most common neuroimmunological disease of the central nervous system in young adults. Despite recommended contraception, unplanned pregnancies can occur in women of childbearing age with MS. MS- and comorbidities-related multimedication in these patients represents a potential risk. We aimed to raise awareness regarding the frequency of polypharmacy and drug-drug interactions (DDIs) in female MS patients of childbearing age.
Methods: Sociodemographic, clinical and pharmaceutical data were collected through patient records, clinical investigations and structured patient interviews of 131 women with MS. The clinical decision support software MediQ was used to identify potential DDIs. A medication and DDI profile of the study population was created by statistical analysis of the recorded data.
Results: Of the 131 female MS patients, 41.2% were affected by polypharmacy (concurrent use of ⩾5 drugs). Polypharmacy was associated with higher age, higher degree of disability, chronic progressive MS disease course and comorbidities. With an average intake of 4.2 drugs per patient, a total of 1033 potential DDIs were identified. Clinically relevant DDIs were significantly more frequent in patients with polypharmacy than in patients without polypharmacy (31.5% 5.2%; Fisher's exact test: < 0.001).
Conclusion: For the first time, a comprehensive range of potential DDIs in women of childbearing age with MS is presented. Polypharmacy is associated with the occurrence of clinically relevant DDIs. This shows the need for effective and regular screening for such interactions in order to prevent avoidable adverse effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758868 | PMC |
| http://dx.doi.org/10.1177/1756286420969501 | DOI Listing |
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