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Cerebrospinal fluid proteomics reveals the innate immunity and blood-brain barrier dysregulation in a patient with multidrug-resistant ventriculitis treated with intrathecal and intravenous polymyxin B.
Heliyon
December 2024
Department of Critical Care Medicine, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen, 518020, China.
is a major pathogen of nosocomial meningitis and ventriculitis. Due to very limited antibiotic treatment options, polymyxins are often used as a last-line therapy. To optimise polymyxin use in the intraventricular environment, cerebrospinal fluid (CSF) proteomics was employed to investigate host-pathogen-polymyxin interactions in a 69-year-old patient with multidrug-resistant ventriculitis treated with a combination of intrathecal (ITH; 50,000 IU q24h/q48h), intraventricular (IVT; 50,000 IU q48h), and intravenous (500,000 IU, q12h) polymyxin B.
View Article and Find Full Text PDFFucosyltransferase 4 upregulates P-gp expression for chemoresistance via NF-κB signaling pathway.
Biochim Biophys Acta Gen Subj
February 2025
Division of Regulatory Glycobiology, Graduate School of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan; Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan. Electronic address:
Article Synopsis
- Multidrug resistance (MDR) complicates the development of effective chemotherapy, with previous research showing that GnT-III expression decreases chemoresistance and that fucosylation is heightened in resistant cell models.
- Using advanced techniques like CRISPR/Cas9, this study created a FUT4 knockout cell line to assess how fucosylation affects drug resistance by analyzing various gene expressions and drug response.
- The findings revealed that knocking out FUT4 lowered P-glycoprotein levels and enhanced drug sensitivity, indicating that FUT4 plays a pivotal role in regulating P-glycoprotein expression through the NF-κB signaling pathway, positioning it as a potential target for overcoming MDR in cancer treatment.
Environmental concentrations of antibiotics induced polymyxin B tolerance in Aeromonas hydrophila.
Sci Total Environ
December 2024
Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China. Electronic address:
Polymyxin B is one of the last lines of defense in infections caused by multidrug-resistant Gram-negative bacteria. Aeromonas hydrophila are important fish pathogens and the occurrence of polymyxin B-resistant A. hydrophila isolates is increasing.
View Article and Find Full Text PDFCo-resistance is the dominant mechanism of co-selection and dissemination of antibiotic resistome in nano zinc oxide polluted soil.
J Hazard Mater
December 2024
National Institute of Technology, NIT Campus PO, Kozhikode, Kerala 673012, India.
The broader soil bacterial community responses at ecotoxicologically relevant levels of nano ZnO (nZnO) focussing on co-selection of antibiotic resistance (AR) were investigated. nZnO imposed a stronger influence than the bulk counterpart (bZnO) on antibiotic resistance genes (ARGs) with multidrug resistance (MDR) systems being predominant (63 % of total ARGs). Proliferation of biomarker ARGs especially for last resort antibiotic like vancomycin was observed and Streptomyces hosted multiple ARGs.
View Article and Find Full Text PDFTargeting breast cancer resistance protein (BCRP/ABCG2) in cancer.
Transl Cancer Res
November 2024
Department of Pathology, Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Breast cancer is one of the most common cancers among women. Nowadays postoperative adjuvant chemotherapy is the mainstay for clinical treatment of breast cancer. However, the emergence of multidrug resistance (MDR) in breast cancer has become a main reason for the failure of clinical chemotherapy.
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