A new unique sesquiterpene lactone, bicyclolamellolactone A (1), was isolated together with two known monocyclofarnesol-type sesquiterpenes, lamellolactones A (2) and B (3), from the Indonesian marine sponge Lamellodysidea sp. (cf. L. herbacea). The planar structure of 1 was assigned based on its spectroscopic data (1D and 2D NMR, HRESIMS, UV, and IR spectra). The relative and absolute configuration of 1 was determined by comparison of its calculated and experimental electronic circular dichroism spectra in combination with NOESY correlations. Compounds 1-3 inhibited bone morphogenic protein (BMP)-induced alkaline phosphatase activity in mutant BMP receptor-carrying C2C12 cells with IC values of 51, 4.6, and 20 μM, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2021.127783 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Denture Care Behavior and Lifespan of Removable Partial Dentures in Indonesian Military Personnel: An Approach Using the Theory of Planned Behavior.
Eur J Dent
December 2024
Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia.
Objectives: In the context of military health, removable partial acrylic dentures (RPADs) are crucial for the quality of life and performance of Indonesian National Armed Forces (TNI) soldiers. Given the demanding and unpredictable military environment, RPADs provide a solution for soldiers experiencing tooth loss. This research aims to identify behavioral factors influencing the lifespan of RPADs among TNI soldiers.
View Article and Find Full Text PDFIn silico study of bioactive compounds derived from Indonesian marine invertebrates as a novel antituberculosis agent.
Turk J Med Sci
December 2024
Research Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, Bogor, Indonesia.
Background/aim: Tuberculosis (TB) has become the world's deadliest disease. The lack of an effective therapeutic drug to treat it is one of the obstacle for doctors. Today, multidrug-resistant TB cases are increasing.
View Article and Find Full Text PDFStatus of coral, giant clam and sea cucumber communities including CITES listed species on a remote Australian coral reef atoll and the potential impact of illegal fishing.
Mar Environ Res
December 2024
Reef Life Survey Foundation, Hobart, 7000, Australia; Institute for Marine and Antarctic Studies, University of Tasmania, Hobart, 7000, Australia.
Following a recent dramatic increase in illegal fishing by Indonesian fishing vessels in Australian waters in 2022, we conducted an extensive survey of coral reef communities covering 33,000 m at Mermaid Reef Marine Park in the Rowley Shoals off north-western Australia in July 2022. Species richness of sea cucumbers was 13 species (three CITES listed) and 6 species of giant clams (all CITES listed). The most abundant sea cucumber species were the low or intermediate value, asexually reproducing species Holothuria atra and H.
View Article and Find Full Text PDFLamellodysideol, a new flexible marine norditerpenoid from the Indonesian marine sponge .
Nat Prod Res
December 2024
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Japan.
One new acyclic norditerpenoid, lamellodysideol () was isolated from the Indonesian marine sponge together with known phytol (). The structure of was determined on the basis of spectral evidence and by comparison with known related molecules including optical rotation data. The relative configurations of and were proposed using quantum chemical calculation of NMR chemical shifts at DFT levels.
View Article and Find Full Text PDFTwo Strains of Endophytic Carrying Antibiotic-Biosynthetic Genes Show Antibacterial and Antibiofilm Activities Against Methicillin-Resistant (MRSA).
Indian J Microbiol
December 2024
Indonesian Marine Education and Research Organisation (MERO) Foundation, Br. Dinas Muntig, Bali, Indonesia.
Unlabelled: Methicillin-resistant (MRSA) is considered a priority pathogen causing high mortality that requires effective control measures. This study aimed to detect the presence of antibiotic-biosynthetic genes and to evaluate the anti-MRSA activity of two strains of endophytic isolated from . PCR-based screening showed that strains, such as DJ4 and DJ9 possessed six antibiotic-biosynthetic genes, namely , and According to the preliminary test conducted using disc-diffusion assay, metabolite extracts from these strains have anti-MRSA activity with clear zone diameters of 13.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!