AI Article Synopsis
- The study assesses whether averaging fasting, 1-hour, and 2-hour plasma glucose levels offers a superior prediction for the future risk of type 2 diabetes (T2DM).
- Over 12 years, data from 7,533 participants were analyzed, showing that the averaged glucose index (GLU) had better hazard ratios and area under the curve metrics than individual glucose measurements.
- The conclusion is that using the mean of these different glucose values is more effective in predicting future T2DM compared to evaluating each glucose measurement separately.
Article Abstract
Aims: The fasting, 1-h, and 2-h plasma glucose (PG) levels during oral glucose tolerance test represent different glucose metabolic functions. We examined whether averaging these PG indices (GLU) results in a better predictor of future type 2 diabetes (T2DM).
Methods: 7533 participants were followed up biannually for 12 years. Hazard ratios (HRs), area under the curve (AUC) of the receiver-operating characteristic, and the net reclassification index (NRI) for T2DM were calculated to compare the discriminative ability of GLU versus other PG indices.
Results: The adjusted HRs and 95% confidence intervals for an increase in SD of GLU was 2.50 (2.36-2.65) and 1.88 (1.73-2.04) in T2DM-free and normal glucose tolerance (NGT) participants, respectively. The AUC of GLU was higher than that of fasting PG, 1-h, and 2-h PG values for T2DM-free (0.79 versus 0.67, 0.77, and 0.73) and NGT (0.73 versus 0.65, 0.72, and 0.61). The model using GLU improved the classification of the models with fasting PG, 1-h, and 2-h PG values (NRI: 0.369, 0.272, and 0.282 for T2DM-free and 0.249, 0.131, and 0.351 for NGT participants with all p < 0.001).
Conclusions: The mean of fasting, 1-h, and 2-h PG levels predicts future T2DM better than each index.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.diabres.2021.108650 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Severe Impact of Omeprazole Timing on pH-Sensitive Dasatinib Absorption: Unveiling Substantial Drug-Drug Interaction.
J Clin Pharmacol
December 2024
Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.
The absorption and bioavailability of most tyrosine kinase inhibitors are affected by gastrointestinal pH as they are weak basic lipophilic drugs. Hence, concomitant use of acid reducing agents (ARAs) is frequently restricted. Particularly comedication of crystalline dasatinib (Sprycel) and proton-pump inhibitors (PPIs) should be avoided.
View Article and Find Full Text PDFReduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial.
Endocrinol Diabetes Metab
January 2025
Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao, China.
Background: With the elevated level of NAFLD prevalence, the incidence of diabetes, hypertension, metabolic syndrome and other diseases is also significantly elevated. GLP-1RA can exert weight loss, glucose-lowering effects and various nonglycaemic effects. However, the relationship between quantitative reduction in hepatic fat content and improvement of pancreatic islet function by GLP-1RA is unclear.
View Article and Find Full Text PDFComparing ADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes in the SHiDS study.
Diabetes Res Clin Pract
December 2024
Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China. Electronic address:
Aims: This study aimed to assess the prevalence of IH and diabetes, as well as insulin secretion, insulin sensitivity, and related curve patterns in subjects with different glucose tolerance categories according to the diagnostic criteria established by the American Diabetes Association (ADA) and the more recently published International Diabetes Federation (IDF) guidelines.
Methods: We used data of 5,387 adult participants from the Shanghai High-risk Diabetic Screen (SHiDS) study. All participants underwent a five-point 75 g oral glucose tolerance test (OGTT).
Association Between Glycemia, Glycemic Variability, and Pregnancy Complications in Early GDM.
Diabetes Care
December 2024
Western Sydney University, Campbelltown, New South Wales, Australia.
Objective: To investigate the association of timing of commencing glucose management with glycemia, glycemic variability, and pregnancy outcomes among women with early gestational diabetes mellitus (GDM).
Research Design And Methods: In this substudy among participants of a trial of immediate vs delayed treatment of early GDM diagnosed by 2013 World Health Organization criteria, all women treated immediately and those with delayed diagnosis at 24-28 weeks' gestation (treated as if late GDM) were instructed to monitor capillary blood glucose (BG) four times a day (fasting and 2-h postprandial) until delivery. Optimal glycemia was defined as ≥95% of BG measurements between 70 and 140 mg/dL (3.
Comparative Transcriptome Analyses Provide Potential Insights into Molecular Mechanisms of Anthocyanin-Rich Blueberry Extract in Rapid Intervention Against Acute Alcohol Exposure in Mice.
Plant Foods Hum Nutr
December 2024
School of Life Sciences, Anhui Agricultural University, Hefei, 230036, China.
Alcohol-induced health damage has become an increasing global public health concern. Anthocyanins exhibit essential biological activities, including antioxidation, anti-inflammation, and lipid reduction. This study investigates the rapid intervention effects and mechanisms of anthocyanin-rich blueberry extract in mitigating acute alcohol exposure in mice, aiming to uncover its novel nutritional roles.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!