Binding and crossing: Methods for the characterization of membrane-active peptides interactions with membranes at the molecular level.

Arch Biochem Biophys

Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, 75005, Paris, France.

Published: March 2021

AI Article Synopsis

  • Antimicrobial and cell-penetrating peptides have been researched for over six decades, initially as separate areas of study.
  • Recent studies have started to draw connections between these two families of peptides, leading to significant methodological advancements.
  • This review highlights innovative developments in the field, including droplet interface bilayers, new fluorescence techniques, force measurement methods, and photolabelling.

Article Abstract

Antimicrobial and cell-penetrating peptides have been the object of extensive studies for more than 60 years. Initially these two families were studied separately, and more recently parallels have been drawn. These studies have given rise to numerous methodological developments both in terms of observation techniques and membrane models. This review presents some of the most recent original and innovative developments in this field, namely droplet interface bilayers (DIBs), new fluorescence approaches, force measurements, and photolabelling.

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Source
http://dx.doi.org/10.1016/j.abb.2021.108751DOI Listing

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