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| http://dx.doi.org/10.1111/dth.14765 | DOI Listing |
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CBX2 suppresses interferon signaling to diminish tumor immunogenicity via a noncanonical corepressor complex.
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State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510050, China.
Chromobox 2 (CBX2), a crucial component of the polycomb repressive complex (PRC), has been implicated in the development of various human cancers. However, its role in the regulation of tumor immunogenicity and immune evasion remains inadequately understood. In this study, we found that ablation of CBX2 led to tumor growth inhibition, activation of the tumor immune microenvironment, and enhanced therapeutic efficacy of anti-PD1 or adoptive T cell therapies by using murine syngeneic tumor models.
View Article and Find Full Text PDFMultiplex Nontargeted Framework Enables Tracking Metabolic Profile of Oxymetholone and Methasterone In Vivo at Nanogram Level by GC-Orbitrap-HRMS for Antidoping Purpose.
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Shanghai University of Sport, 399 Changhai Road, Shanghai 200438, China.
Oxymetholone and methasterone are anabolic androgenic steroids prohibited by the World Anti-Doping Agency (WADA) for both in-competition and out-of-competition use. Detecting metabolites of exogenous steroids is crucial for establishing doping violations, making the study of these metabolites essential in antidoping efforts. This study investigated the urinary metabolic profiles of oxymetholone and methasterone using gas chromatography-orbitrap high-resolution mass spectrometry (GC-Orbitrap-HRMS) in nanogram level by utilizing a novel multiplex nontargeted framework protocol.
View Article and Find Full Text PDFDysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity.
mSphere
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Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually causing local outbreaks and epidemics. While all three newly emerging human CoVs from the past 20 years (SARS-CoV, SARS-CoV-2, and MERS-CoV) cause respiratory disease, each CoV has unique host interactions that drive differential pathogeneses.
View Article and Find Full Text PDFThe interplay between individual capacities and pair performance according to the experience in Acrobatic Gymnastics.
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Centre for Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sports, University of Porto, Porto, Portugal.
The interplay between individual capacities and group performance provides insights for different tasks and contexts. So far, little is known about the individual capacities of base and top gymnasts and mechanical efficiency during pair tasks of Acrobatic Gymnastics. This work aims to investigate: (1) the effect of the pair experience in the mechanical efficiency during a pair task; (2) the effect of the individual training experience in the gymnasts' individual capacities, and (3) the contribution of individual capacities and pair mechanical efficiency to the performance of a partner-assisted flight task.
View Article and Find Full Text PDFEvaluating the Impact of Preoperative Nutritional Status on Surgical Outcomes and Public Health Implications in General Surgery Patients.
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General Surgery, Institute DHQ Hospital Dassu, Upper Kohistan, PAK.
Background: Malnutrition is linked to more postoperative problems, a longer recovery period, and a higher death rate; preoperative nutritional condition is a critical factor in surgical outcomes.
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Methodology: A two-year observational research with 440 adult patients undergoing general surgery was carried out between January 2022 and December 2023.
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