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| http://dx.doi.org/10.1038/s41423-020-00605-4 | DOI Listing |
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A 21st-century update of Claude Bernard's Theory about the Constancy of the Internal Environment.
Neuropsychopharmacol Hung
December 2024
Municipal Clinic of Szentendre, Internal Medicine, Szentendre, Hungary.
The discovery of the functioning of intra- and extracellular ion compartments and cell membranes' operation opened the possibility of extending Claude Bernard's theory to intracellular ions. In contrast, by underestimating the role of ions, many misconceptions have prevailed. The author points out that maintaining the constancy of carbon dioxide is especially important.
View Article and Find Full Text PDFComparative analysis of the stress and immune responses in Atlantic salmon (Salmo salar) inoculated with live and inactivated Piscirickettsia salmonis.
Fish Shellfish Immunol
January 2025
Laboratorio de Inmunología y Estrés de Organismos Acuáticos, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile; Centro Fondap Interdisciplinary Center for Aquaculture Research (INCAR), Universidad Austral de Chile, Valdivia, Chile. Electronic address:
Piscirickettsiosis causes the highest mortality in Atlantic salmon (Salmo salar) farming, and prophylactic treatment has not provided complete protection to date. In this study, we analyzed the immune and metabolic responses of Atlantic salmon inoculated with live and inactivated Piscirickettsia salmonis, monitoring plasma markers related to immune and stress responses. The fish were inoculated with inactivated P.
View Article and Find Full Text PDFProteomic characterization of molecular mechanisms of paraquat-induced lung injury in a mouse model.
Respir Res
January 2025
Emergency Department, The First Hospital of China Medical University, No.155 North Nanjing Street, Heping District, Shenyang, Liaoning, 110001, China.
Background: We sought to explore the molecular mechanisms underpinning acute lung injury (ALI) caused by poisoning with paraquat (PQ).
Methods: Selection mice were intraperitoneally injected with PQ at 40 mg/kg, whereas controls were injected with sterile saline. On days 2, 7, and 14 after administration, mice were anesthetized and sacrificed, and lung tissue was removed.
Evidence linking cadmium and/or lead exposure to immunomodulatory effects in mammals based upon an adverse outcome pathways approach, and research perspectives.
Chemosphere
January 2025
Laboratoire Chrono-Environnement, UMR 6249, CNRS/Université de Franche-Comté, 16 route de Gray, 25000, Besançon, France.
For decades, studies have shown how exposure to non-essential trace metals such as lead (Pb) and cadmium (Cd) largely impact global wildlife. Ecoimmunotoxicology has emerged in the past two decades and focuses on the effects of pollutants on the immune system of free-ranging organisms. Adverse outcome pathways (AOPs) represent a conceptual approach to explore the mechanistic linkage between a molecular initiating event and adverse outcomes, potentially at all biological levels of organisation.
View Article and Find Full Text PDFConstruction and immunological evaluation of recombinant adenovirus vaccines of new novel NADC34-PRRSV strains in pigs.
Front Vet Sci
December 2024
Changchun Veterinary Research Institute, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Chinese Academy of Agricultural Sciences, Changchun, China.
Introduction: Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive and respiratory diseases in sow herds and piglets. The emergence of ORF5 RFLP 1-7-4-like (NADC34-like) PRRSV strain in China has brought a new round of challenges to PRRSV prevention.
Methods: In addition, recombinant adenovirus vaccine candidates against the newly emerged NADC34-like strain were constructed in the study; the immunogenicity of the vaccine was investigated in piglets.
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