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Decreased sensitivity to risk levels in ventral stratum in major depressive disorder during risky decision-making. | LitMetric
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Decreased sensitivity to risk levels in ventral stratum in major depressive disorder during risky decision-making.

Feng Gao Jie Fan Jie Xia Tamini Soondrum Wanting Liu Hongyu Du Jiang Zhu Changlian Tan Xiongzhao Zhu

J Affect Disord

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China. Electronic address:

Published: March 2021

AI Article Synopsis

  • This study examined decision-making abilities in people with major depressive disorder (MDD) using the balloon analog risk task (BART) and functional MRI.
  • It found that while behavioral performance was similar between MDD patients and healthy controls, MDD patients showed reduced brain activation in the left ventral striatum (VS) when faced with different levels of risk.
  • The results suggest that those with MDD have less sensitivity to risk, indicating a potential issue with how they process rewards in decision-making scenarios.

Article Abstract

Background: Reduced decision-making ability in depressive people has been observed both in daily life and experimental behavioral studies. However, the neurobiology of dysfunction in decision-making among depressive people is still unclear.

Methods: The study included 63 patients with major depressive disorder (MDD) and 49 healthy controls (HCs). The balloon analog risk task (BART), a risky decision-making paradigm, was used in a functional magnetic resonance imaging experiment to evaluate how brain activation was modulated by different levels of risk.

Results: No significant difference in behavioral performance was found. In prespecified brain regions, the activation of the left ventral stratum (VS) in MDD patients showed reduced modulation by risk levels compared with HCs. No significant group difference was found in prespecified dorsal anterior cingulate cortex (dACC) and right dorsal lateral prefrontal cortex (DLPFC).

Limitations: BART did not isolate stages of making a choice and experiencing the outcome of the choice.

Conclusion: The left VS was less sensitive to risk levels in MDD patients compared with HCs, indicating inefficient reward processing in risky decision-making in MDD.

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 Source
http://dx.doi.org/10.1016/j.jad.2020.12.131DOI Listing

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