AI Article Synopsis
- Mice exposed to 1,500 to 3,000 rads of X-ray on the left hind leg showed a decrease in leukocyte counts.
- Pre-treatment with lentinan completely protected the mice from this reduction in leukocyte counts caused by X-ray exposure.
- The combination of lentinan treatment (either before or after X-ray) in mice with solid type sarcoma 180 produced an additive effect, suggesting some level of benefit in cancer treatment.
Article Abstract
Apparent reduction of leukocyte counts was observed in mice irradiated with 1,500 approximately 3,000 rads of X-ray on the left hind leg. This reduction of leukocyte counts was completely protected by the pre-treatment with lentinan before X-ray irradiation. Suppressive effect of X-ray on the antitumor function of lentinan seems to be weak. When treatment with X-ray irradiation and lentinan was applied for mice bearing solid type sarcoma 180, additive effect was obtained by the combination of lentinan before or after X-ray irradiation.
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