Bacterial Transcription Continues to Surprise: Activation by Alarmone-Mediated σ-Factor Tethering.

Mol Cell

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

Published: January 2021

Travis et al. (2020) reveal how Francisella tularensis uses stress-induced ppGpp to activate its virulent pathogenesis program by tethering an αCTD-DNA organizer (PigR) to a σ-organizing heterodimer (MglA-SspA), highlighting the remarkable diversity of transcriptional mechanisms in under-studied bacteria.

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http://dx.doi.org/10.1016/j.molcel.2020.12.031DOI Listing

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