Rapidly advancing solutions requires our community to continuously re-examine successes of yesterday to inspire new approaches for today while collaboratively envisioning what’s needed for tomorrow.
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| http://dx.doi.org/10.1093/abm/kaaa092 | DOI Listing |
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The connecting brain in context: How adolescent plasticity supports learning and development.
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University of California, Los Angeles, CA, USA.
Puberty initiates significant neurobiological changes that amplify adolescents' responsiveness to their environment, facilitating neural adaptation through processes like synaptic pruning, myelination, and neuronal reorganization. This heightened neuroplasticity, combined with their burgeoning social curiosity and appetite for risk, propels adolescents to explore diverse new environments and forge social bonds. Such exploration can accelerate experiential learning and the formation of social networks as adolescents prepare for adult independence.
View Article and Find Full Text PDFIdentity Work: A Qualitative Study of Residents' Experiences Navigating Identity Struggles.
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Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Introduction: Medical training traditionally holds a deterministic view of professional socialization wherein many medical learners struggle to construct a professional identity. Previous research has demonstrated the dysfunctional norms and conflicting ideologies that create identity struggle, disproportionally affecting women and individuals underrepresented in medicine. Symbolic interactionism can help explain identity struggles, emphasizing the influence of socio-contextual factors on identity construction.
View Article and Find Full Text PDFDiversity, Equity, and Inclusion in Veterinary Medicine: Continuing to Forge a Path Forward Together.
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Remote C─H Bond Activation via Enantioselective Carbopalladation and 1,4-Pd Migration Cascade Process.
Adv Sci (Weinh)
October 2024
Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, China.
Article Synopsis
- The study introduces an asymmetric palladium-catalyzed tandem carbopalladation reaction that effectively activates remote C─H bonds, enabling the formation of valuable tetracyclic dihydroindeno[1,2,3-de]chromene compounds with a chiral fluorene structure.
- This reaction operates under mild conditions and demonstrates a wide functional group tolerance, achieving good to excellent enantioselectivities, making it a powerful synthetic tool for producing complex organic molecules.
- Furthermore, theoretical calculations suggest that the protonation of a specific palladacycle intermediate is more energetically favorable than its direct breakdown, shedding light on the reaction's mechanism and potential enhancements.
A novel step towards the heterologous biosynthesis of paclitaxel: Characterization of T1βOH taxane hydroxylase.
Metab Eng
September 2024
Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:
In the quest for innovative cancer therapeutics, paclitaxel remains a cornerstone in clinical oncology. However, its complex biosynthetic pathway, particularly the intricate oxygenation steps, has remained a puzzle in the decades following the characterization of the last taxane hydroxylase. The high divergence and promiscuity of enzymes involved have posed significant challenges.
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