The structural elucidation of chiral molecules with more than one stereocenter is usually a tricky problem. In this paper, efficient H NMR spectroscopic approaches for assigning the and configurations of 1-oxygenated 1,2-diarylpropan-3-ols were developed. By analysis of the chemical shift differences of diastereotopic methylene H-3 (Δδ) in CDCl or the chemical shift differences of H-1 and H-2 (Δδ) in methanol-, deuterated dimethyl sulfoxide, and acetone-, the configurations of 1-oxygenated 1,2-diarylpropan-3-ols can be rapidly and conveniently determined.
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The structural elucidation of chiral molecules with more than one stereocenter is usually a tricky problem. In this paper, efficient H NMR spectroscopic approaches for assigning the and configurations of 1-oxygenated 1,2-diarylpropan-3-ols were developed. By analysis of the chemical shift differences of diastereotopic methylene H-3 (Δδ) in CDCl or the chemical shift differences of H-1 and H-2 (Δδ) in methanol-, deuterated dimethyl sulfoxide, and acetone-, the configurations of 1-oxygenated 1,2-diarylpropan-3-ols can be rapidly and conveniently determined.
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