Compared to mono-species biofilm, biofilms formed by cross-kingdom pathogens are more refractory to conventional antibiotics, thus complicating clinical treatment and causing significant morbidity. Lemongrass essential oil and its bioactive component citral were previously demonstrated to possess strong antimicrobial efficacy against pathogenic bacteria and fungi. However, their effects on polymicrobial biofilms remain to be determined. In this study, the efficacy of lemongrass () essential oil and its bioactive part citral against dual-species biofilms formed by and species was evaluated . Biofilm staining and viability test showed both lemongrass essential oil and citral were able to reduce biofilm biomass and cell viability of each species in the biofilm. Microscopic examinations showed these agents interfered with adhesive characteristics of each species and disrupted biofilm matrix through counteracting nucleic acids, proteins and carbohydrates in the biofilm. Moreover, transcriptional analyses indicated citral downregulated hyphal adhesins and virulent factors of , while also reducing expression of genes involved in quorum sensing, peptidoglycan and fatty acids biosynthesis of . Taken together, our results demonstrate the potential of lemongrass essential oil and citral as promising agents against polymicrobial biofilms as well as the underlying mechanisms of their activity in this setting.
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http://dx.doi.org/10.3389/fcimb.2020.603858 | DOI Listing |
J Ethnopharmacol
December 2024
MecNano Technologies, Cube Incubation, Teknopark Istanbul, Istanbul, 34906, Türkiye; Department of Pharmacology, Faculty of Pharmacy, Istanbul Kent University, Istanbul, 34406, Türkiye; UCL Division of Surgery and Interventional Sciences, Rowland Hill Street, NW3 2PF, London, UK; Art de Huile, Teknopol Istanbul, Istanbul, 34930, Türkiye; Biomedical Engineering Department, University of Aveiro, Aveiro, 3810-193, Portugal. Electronic address:
Ethnopharmacological Relevance: Clove is used in Indian and Chinese traditional medicine for viral diseases. Palmarosa essential oils have been traditionally used in India and Southeast Asia since ancient times and have made considerable use of them. In New Caledonia, niaouli oil is used in aromatherapy and pharmaceutical formulations to treat pain and viral diseases.
View Article and Find Full Text PDFPathophysiology
November 2024
Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ministry of Chemicals and Fertilizers, Government of India, Hyderabad 500037, Telangana, India.
To investigate the anti-inflammatory, antioxidant, and diabetic wound healing properties of the novel topical formulation [Ferulic acid-loaded nanoemulgel (DLMGO-G)]. Ferulic acid nanoemulsion developed with lemongrass oil is investigated in diabetic wound healing. Further nanoemulsion is incorporated into 1% carbopol 934 to obtain the DLMGO-G.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Horticulture, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh.
The present investigation "Effect of essential oils and chia seed () in fortification of pineapple jam." was conducted during the year 2022-2023 at the Post harvest laboratory of Horticulture Department, Sher-e-Bangla Agricultural University, Dhaka. The study investigated the effects of essential oil and chia seeds on the quality of pineapple jam.
View Article and Find Full Text PDFBiochem Mol Biol Educ
December 2024
Chemistry Department, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.
Bacteria have developed a cell-to-cell communication system called quorum sensing (QS), allowing them to regulate group behavior and synchronize the expression of virulence factors, responsible for increasing their infection capacity and resistance to antimicrobials. Although the control of microbial infections through the inhibition of microbial growth has traditionally been the basis of antimicrobial chemotherapy, the emergence of antimicrobial resistance has led to the search for new microbial control strategies, namely through the inhibition of QS. Among the agents studied to inhibit this bacterial communication are essential oils (EO), which are considered very effective QS inhibitors.
View Article and Find Full Text PDFPoult Sci
December 2024
Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Australia. Electronic address:
The early post-hatching phase remains to be one of the most vulnerable phases in broiler production. Some essential oils have been reported to improve gut health and growth in broiler chickens when applied to post-hatching diets. However, in-feed applications are unable to prevent the health challenges observed immediately after hatching.
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