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Impact of Opioid Consumption in Patients With Functional Gastrointestinal Disorders. | LitMetric

Impact of Opioid Consumption in Patients With Functional Gastrointestinal Disorders.

Front Pharmacol

INSERM UMR 1073, Institute for Research and Innovation in Biomedicine, Normandy University, Rouen, France.

Published: December 2020

AI Article Synopsis

  • - The study evaluated opioid consumption among patients with functional gastrointestinal disorders from 2013 to 2019, including conditions like irritable bowel syndrome and functional dyspepsia, to assess its impact on their health.
  • - Out of 2,933 patients, the rates of opioid usage (tramadol, step II, and step III) significantly increased from 2013 to 2018, indicating a growing trend in opioid dependency within this group.
  • - Increased opioid use was linked to worse gastrointestinal symptoms (like vomiting and constipation), higher severity of symptoms, diminished quality of life, and increased depression scores.

Article Abstract

We aimed to determine the burden of opioid consumption in a cohort of patients with functional gastrointestinal disorders. All patients diagnosed with functional gastrointestinal disorders and referred to our university hospital were evaluated from 2013 to the beginning of 2019. Irritable bowel syndrome and functional dyspepsia diagnoses were determined according to Rome criteria and severity according to irritable bowel syndrome severity scoring system. Vomiting was quantified using a 5-point Likert scale, and constipation severity was measured using the Knowles-Eccersley-Scott-Symptom questionnaires. Quality of life was quantified by the GastroIntestinal Quality of Life Index. Patients were categorized as being treated on a chronic basis with either tramadol, step II opioids, step III opioids or as being opioid-free. 2933 consecutive patients were included. In our cohort, 12.5% had only irritable bowel syndrome, 39.3% had only functional dyspepsia, 24.9% had a combination of both, and 23.4% had other functional gastrointestinal disorders. Among them, the consumption of tramadol, step II (tramadol excluded) and step III opioids was 1.8, 1.3 and 0.3 % respectively in 2013 and 4.3, 3.4 and 1.9% in 2018 ( < 0.03). Opioid consumption was associated with increased vomiting ( = 0.0168), constipation ( < 0.0001), symptom severity ( < 0.001), more altered quality of life ( < 0.0001) and higher depression score ( = 0.0045). In functional gastrointestinal disorders, opioid consumption has increased in the last years and is associated with more GI symptoms (vomiting, constipation and GI severity), higher depression and more altered quality of life.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783866PMC
http://dx.doi.org/10.3389/fphar.2020.596467DOI Listing

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