AI Article Synopsis
- HCMV is a β-herpesvirus that causes lifelong latency and inflammation, with recent findings linking it to rheumatoid arthritis (RA) and bone erosion.
- Infection with HCMV seems to slow down bone erosion in RA patients by promoting the mRNA-binding protein QKI5, which raises questions about its role in RA's progression.
- This review explores whether HCMV acts as a beneficial factor against bone erosion while potentially aggravating RA inflammation, also considering its interactions with other pathogens like those causing periodontitis.
Article Abstract
Human cytomegalovirus (HCMV) is a β-herpesvirus that causes inflammation and remains for life in a latent state in their host. HCMV has been at the center of many hypotheses regarding RA.We have recently shown that HCMV infection impairs bone erosion through the induction of the mRNA-binding protein QKI5. Latently infected RA patients display a slower progression of bone erosion in patients from a national cohort. Our observations question the possible association between HCMV and the pathophysiology of RA. In this review, we examine the possibility that HCMV may be an aggravating factor of inflammation in RA while protecting from bone erosion. We also assess its relationship with other pathogens such as bacteria causing periodontitis and responsible for ACPA production.This review thus considers whether HCMV can be regarded as a friend or a foe in the pathogenesis and the course of RA.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792325 | PMC |
| http://dx.doi.org/10.1186/s13075-020-02398-3 | DOI Listing |
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