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| http://dx.doi.org/10.1016/j.kint.2020.12.020 | DOI Listing |
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Associations between inflammation and striatal dopamine D2-receptor availability in aging.
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Department of Medical and Translational Biology, Umeå university, Umeå, 901 87, Sweden.
Background: Normal brain aging is associated with dopamine decline, which has been linked to age-related cognitive decline. Factors underlying individual differences in dopamine integrity at older ages remain, however, unclear. Here we aimed at investigating: (i) whether inflammation is associated with levels and 5-year changes of in vivo dopamine D2-receptor (DRD2) availability, (ii) if DRD2-inflammation associations differ between men and women, and (iii) whether inflammation and cerebral small-vessel disease (white-matter lesions) serve as two independent predictors of DRD2 availability.
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Department of Twins Research and Genetic Epidemiology, King's College London, London, United Kingdom. Electronic address:
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Department of Public Health Sciences, Miller School of Medicine, 5452 University of Miami, Miami, FL, USA.
Objectives: This study aimed to examine the relationship between marijuana use and aggression and victimization among Colombian adolescents. We aimed to clarify marijuana's distinct role by comparing different categories of drug use and by considering the order of drug initiation.
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Cerebral autosomal-dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is the most prevalent monogenic inherited cause of cerebral small-vessel disease. Despite its prevalence, there is currently no proven therapy to prevent or reverse the progression of the disease. This study aimed to characterize the functional integrity of long white matter tracts in CADASIL transgenic mice, both with and without focal white matter lesions in the corpus callosum added on, utilizing optical resting-state functional connectivity imaging alongside behavioral examinations.
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