In this issue of Neuron, Kar and DiCarlo (2021) demonstrate that feedback from ventrolateral prefrontal cortex (VLPFC) to inferotemporal cortex (IT) is required for object recognition. They show that inactivating VLPFC selectively degrades object recognition performance and population encoding of object identity in IT.
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http://dx.doi.org/10.1016/j.neuron.2020.12.014 | DOI Listing |
Dokl Biochem Biophys
January 2025
Center for Strategic Planning and Management of Biomedical Health Risks, Federal Medical and Biological Agency, Moscow, Russia.
Unlabelled: The association of the pathogenesis of neurodegenerative diseases, depression, anxiety, and cognitive disorders with neurotrophin-3 deficiency determines the prospect of creating drugs with a similar mechanism of action. Since the use of full-length NT-3 is limited by unsatisfactory pharmacokinetic properties, the creation of low-molecular mimetics of neurotrophin-3 that are active when administered systemically is relevant. The Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies has created a dimeric dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-γ-oxybutyryl-L-glutamyl-L-asparagine) with the laboratory code GTS-302, which activates TrkC and TrkB receptors.
View Article and Find Full Text PDFNeuroinformatics
January 2025
Institute of Mathematics, University of Kassel, Heinrich-Plett-Str. 40, Kassel, 34132, Germany.
Accurately identifying the timing and frequency characteristics of impulse components in EEG signals is essential but limited by the Heisenberg uncertainty principle. Inspired by the visual system's ability to identify objects and their locations, we propose a new method that integrates a visual system model with wavelet analysis to calculate both time and frequency features of local impulses in EEG signals. We develop a mathematical model based on invariant pattern recognition by the visual system, combined with wavelet analysis using Krawtchouk functions as the mother wavelet.
View Article and Find Full Text PDFGeroscience
January 2025
Department of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin St., Houston, TX, 77030, USA.
Alzheimer's disease (AD) is a neurodegenerative disorder that affects more than 6.2 million Americans aged 65 and older, particularly women. Along with AD's main hallmarks (formation of β-amyloid plaques and tau neurofibrillary tangles), there are vascular alterations that occurs in AD pathology.
View Article and Find Full Text PDFBehav Brain Res
January 2025
Laboratorio de Neurobiología, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica (IPICYT), San Luis Potosí, Mexico. Electronic address:
Ketamine hydrochloride serves multiple purposes, including its use as a general anesthetic, treatment for depression, and recreational drug. In studies involving rodents, ketamine is utilized as a model for schizophrenia. However, it is unclear whether age affects the behavioral response induced by repeated ketamine administration and if it modifies the expression levels of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and purinergic receptors (P2X1, P2X4, P2X7).
View Article and Find Full Text PDFElife
January 2025
Department of Psychology, University of York, North Yorkshire, United Kingdom.
Processing pathways between sensory and default mode network (DMN) regions support recognition, navigation, and memory but their organisation is not well understood. We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that support visually mediated semantic and spatial cognition, providing convergent evidence from univariate and multivariate task responses, intrinsic functional and structural connectivity. Participants learned virtual environments consisting of buildings populated with objects, drawn from either a single semantic category or multiple categories.
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