AI Article Synopsis
- The study explores the potential of modifying cell surface glycans for disease treatment, focusing on a specific glycomimetic of l-fucose.
- This glycomimetic significantly inhibits the production of sLe by certain enzymes (FTVI and FTVII), but does not impact the production of Le by another enzyme (FTIX).
- Additionally, the research shows that this glycomimetic does not interfere with GDP-fucose binding at the enzyme's active site, suggesting a selective approach to suppressing sLex.
Article Abstract
The ability to custom-modify cell surface glycans holds great promise for treatment of a variety of diseases. We propose a glycomimetic of l-fucose that markedly inhibits the creation of sLe by FTVI and FTVII, but has no effect on creation of Le by FTIX. Our findings thus indicate that selective suppression of sLex display can be achieved, and STD-NMR studies surprisingly reveal that the mimetic does not compete with GDP-fucose at the enzymatic binding site.
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| http://dx.doi.org/10.1039/d0cc04847j | DOI Listing |
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