Exploration of endoscopic findings and risk factors of early gastric cancer after eradication of .

Aim: To explore the endoscopic features and risk factors of early gastric cancer (EGC) after eradication of ().

Methods: A total of 1961 patients who underwent esophago-gastro-duodenoscopy (EGD) with a history of successful eradication were enrolled in this multicenter research. Among them, 162 EGC lesions of 132 patients were detected. The endoscopic features and risk factors of post-eradication EGC were explored.

Results: Severe atrophy (75.3% vs. 16.7%, value <.01), intestinal metaplasia (96.3% vs. 77.1%, value <.01), map-like redness (89.5% vs. 65.4%, value <.01), distinct intermediate zone (IZ) (68.5% vs. 23.4%, value <.01) and xanthoma (58.0% vs. 17.9%, value <.01) were significantly more frequent in the CA group (patients with newly detected EGC after eradication of ) than in the NC group (patients without gastric cancer after eradication of ). In multivariate analysis, severe atrophy (odds ratio (OR) = 8.08; 95% confidence interval (CI), 3.43-20.0; value<.01), map-like redness (OR = 1.75; 95% CI, 0.11-5.25; value = .04), distinct IZ (OR = 2.87; 95% CI, 1.20-6.93; value = .02) and xanthoma (OR = 2.84; 95% CI, 1.20-7.03; value=.02) were proved to be risk factors for detection of EGC after eradication of .

Conclusions: Severe atrophy and map-like redness and distinct IZ and xanthoma are risk factors of EGC after eradication of .