AI Article Synopsis
- "Open-ended" molecular techniques like 16S rRNA sequencing have shown that the diversity of bacteria in subgingival plaque is greater than previously understood.
- It has been found that the composition of bacteria remains qualitatively similar in both healthy and diseased states, but they differ significantly in their abundance.
- Analysis indicates that interactions among these bacterial communities play a crucial role in the development of dysbiosis and gum disease, while unique bacteriome signatures may be useful for diagnosing and managing oral health issues.
Article Abstract
"Open-ended" molecular techniques such as 16S rRNA sequencing have revealed that the oral bacteriome of subgingival plaque is more diverse than originally thought. 16S rRNA analysis has demonstrated that constituents of the overall bacterial community are qualitatively similar in health and disease, differing mainly in their relative proportions with respect to each other. Species in low abundance can also act as critical species, leading to the concept of global community dysbiosis which relates to shifts in community structure, rather than shifts in membership. Correlation analysis suggests that coordinated interactions in the community are essential for incipient dysbiosis and disease pathogenesis. The subgingival bacteriome also provides biomarkers that are useful for disease detection and management. Combined with clinical and biological parameters, these may assist clinicians in developing and implementing effective treatment strategies to restore microbial homeostasis and monitor disease. Identification of higher risk groups or poor responders to treatment using unique subgingival bacteriome signatures may also lead to early intervention.
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Article Synopsis
- "Open-ended" molecular techniques like 16S rRNA sequencing have shown that the diversity of bacteria in subgingival plaque is greater than previously understood.
- It has been found that the composition of bacteria remains qualitatively similar in both healthy and diseased states, but they differ significantly in their abundance.
- Analysis indicates that interactions among these bacterial communities play a crucial role in the development of dysbiosis and gum disease, while unique bacteriome signatures may be useful for diagnosing and managing oral health issues.
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