Exposure factors (e.g., ingestion volume and frequency) are required to establish risk-based treatment requirements (i.e., log reduction targets (LRTs)) for enteric pathogens using quantitative microbial risk assessment (QMRA). However, data to Wastewater characterize nonpotable exposure factors are sparse. We calculated graywater and wastewater nonpotable LRTs (corresponding to 10 infections per person per year) for uses missing detailed exposure data (including showering and decorative fountain) and across a range of exposure factors. The LRTs decreased linearly toward zero as the log transformed volume or the frequency of reuse decreased. When nonroutine exposure was included, representing either accidental ingestion from misuse or cross-connection between potable and nonpotable waters, the LRTs remained high, even as the routine ingestion volume decreased. Therefore, uses with small anticipated routine ingestion volumes (i.e., roughly <10 L), e.g., domestic indoor or decorative fountain uses, share common LRTs, and further refinement of the routine exposure is of limited value. Additional data to characterize nonroutine exposures and uses with high routine ingestion, e.g., showering, remain valuable to better estimate LRTs. These results will assist regulators in the selection of LRTs for nonpotable uses that lack detailed exposure factor characterizations.
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http://dx.doi.org/10.1021/acs.estlett.0c00752 | DOI Listing |
Background: The armamentarium of medical therapies to treat inflammatory bowel disease (IBD) continues to grow, which has expanded treatment options, particularly after first biologic failure. Currently, there are limited studies investigating the predictive value of first biologic primary non-response (PNR) on subsequent biologic success. Our objective was to determine if PNR to the first biologic for IBD is predictive of response to subsequent biologic therapy.
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Cosmetics Europe, Brussels, Belgium.
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.
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Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, China.
While recent studies have indicated a potential link between incense burning and respiratory diseases, there is a lack of data specifically focused on diabetic patients. To explore the relationship between indoor incense burning and impaired lung function among Chinese individuals with diabetes, a comprehensive cross-sectional study was undertaken, enrolling 431 adults diagnosed with diabetes. Information on incense burning and characteristics was collected using a structured questionnaire.
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Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
China has implemented the "tiered medical services" policy since 2015, while there is a paucity of data evaluating the the current status of chronic obstructive pulmonary disease (COPD) management under the system. Characteristics and treatments from 11,905 COPD patients in 88 hospitals across different tiers in China were included and analyzed. We assessed the statistical significance of differences by one way analysis of variance (ANOVA) for continuous variables and with the chi-squared test for categorical variables.
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January 2025
College of Veterinary Medicine and Agriculture, Addis Ababa University, Addis Ababa, Ethiopia.
Bovine viral diarrhea (BVD) is a highly infectious disease affecting cattle, leading to significant economic losses in many countries engaged in cattle production. From February 2022 to October 2022, a study was conducted to determine the seroprevalence and associated risk factors of Bovine Viral Diarrhea Virus (BVDV) in the Sebeta subcity area of Sheger city, Ethiopia. The study utilized a semi-structured questionnaire to gather information on herd management practices from dairy farm owners.
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