Acquired hemophilia A (AHA) is a bleeding diathesis caused by the production of autoantibodies to factor VIII (FVIII). It manifests as an isolated deranged activated partial thromboplastin time (aPTT) indicating a defect in the intrinsic coagulation pathway. Herein, we report a case of a 26-year-old woman who presented with hemoperitoneum in the postpartum period following a lower segment Caesarean section (LSCS). AHA carries significant mortality if it remains undiagnosed, and early recognition and measures to eradicate the acquired inhibitors are the mainstays of its management.
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| http://dx.doi.org/10.7759/cureus.11817 | DOI Listing |
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Postpartum Acquired Hemophilia A.
J Community Hosp Intern Med Perspect
September 2024
Department of Internal Medicine, Charleston Area Medical Center Institute for Academic Medicine, WV 25304, USA.
Article Synopsis
- * A rare case showcases a 31-year-old woman with sickle cell trait who experienced severe bleeding after a C-section, leading to a diagnosis of postpartum AHA based on lab results showing elevated aPTT and factor VIII inhibitors.
- * Treatment for postpartum AHA focuses on controlling bleeding and eliminating factor VIII inhibitors, but the link between AHA and other blood disorders like sickle cell trait is still not well understood.
Severe case of postpartum-acquired haemophilia A after laparoscopic cholecystectomy.
BMJ Case Rep
March 2024
Department of Surgery, Prisma Health Upstate, Greenville, South Carolina, USA
Acquired factor VIII inhibitor, also known as acquired haemophilia A, has been associated with the postpartum state in young females. Treatment of acquired haemophilia A is focused on two goals: control of bleeding and eliminating the factor VIII inhibitor. Management requires successful intervention to accomplish both goals.
View Article and Find Full Text PDFPostpartum-acquired hemophilia A: case report.
Rev Peru Med Exp Salud Publica
January 2024
Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú.
Acquired hemophilia A is a rare bleeding disorder worldwide, characterized by the presence of inhibitory autoantibodies directed against a coagulation factor, most often factor VIII. There are several possible causes, and it can occur during the postpartum period. We present the case of a 34-year-old female patient with back pain, hematuria and a right gluteal hematoma, with no previous history of bleeding.
View Article and Find Full Text PDFPostpartum-acquired hemophilia A: Experience from a tertiary center in South India.
Int J Gynaecol Obstet
August 2022
Department of Clinical Hematology, Amrita Institute of Medical Sciences, Cochin, India.
Acquired haemophilia A in the postpartum and risk of relapse in subsequent pregnancies: A systematic literature review.
Haemophilia
March 2021
Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratories and Pathology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Background: About 1%-5% of acquired haemophilia A cases affect mothers in the postpartum setting.
Aims: This study delineates the characteristics of this disease, specific to the postpartum setting, notably relapse in subsequent pregnancies.
Methods: Report of two cases and literature study (1946-2019), yielding 73 articles describing 174 cases (total 176 cases).
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