AI Article Synopsis
- The study investigates the link between IL-35 gene polymorphisms and coronary heart disease (CHD) risk in a large Han population in China.
- The researchers used logistic regression and multifactor dimensionality reduction to analyze how specific gene variants (SNPs) interact with environmental factors such as smoking.
- Findings showed that the C allele of rs428253 and the G allele of rs2243115 are associated with a higher risk of CHD, particularly in smokers, highlighting the influence of both genetics and lifestyle on disease susceptibility.
Article Abstract
Background: The relationship between IL-35 genes polymorphism and susceptibility to coronary heart disease has not been tested in the largest Han population in China. The aim of this study was to explore the effect of single nucleotide polymorphisms (SNPs) of interleukin-35 (IL-35) genes and its relationship with environment on the risk of coronary heart disease (CHD).
Methods: We performed Hardy-Weinberg equilibrium test on the control group. The relationship between the four SNPs of IL-35 genes and the risk of coronary heart disease was studied by multivariate logistic regression. The best interaction was identified with generalized multifactor dimensionality reduction (GMDR). Logistic regression was used for investigation on association between four SNPs and CHD risk.
Results: Logistic regression analysis showed that the C allele of rs428253 and the G allele of rs2243115 were independently correlated with increased risk of CHD, and adjusted ORs (95% CI) were 1.91 (1.28-2.64) and 1.80 (1.30-2.23), respectively. However, there was no significant association between CHD and rs4740 or rs568408. GMDR model indicated a best model for CHD risk consisted of rs428253 and current smoking, which scored 10/10 for both the sign test and cross-validation consistency (p = 0.010). Therefore, this overall multi-dimensional model had the highest cross-validation consistency, regardless of how the data were divided. This provided an evidence of gene-environment interaction effects. We also found that current smokers with rs428253-GC/CC genotype have the highest CHD risk, compared to never smokers with rs428253-GG genotype, OR (95% CI) = 3.04 (1.71-4.41), after adjustment for age, gender, hypertension, T2DM and alcohol consumption status.
Conclusions: In this study, the C allele of rs428253 and the G allele of rs2243115, and the interaction rs428253 and current smoking were correlated with increased risk of CHD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789631 | PMC |
| http://dx.doi.org/10.1186/s12872-020-01811-8 | DOI Listing |
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