The aim was to evaluate the efficacy and safety of chimeric antigen receptor T (CAR-T) cell in B-cell non-Hodgkin lymphoma (B-NHL). A meta-analysis was conducted using eligible clinical trials, which were obtained from electronic medical literature databases. A total of 24 clinical trials with 590 patients were included. The best overall response rate was 66% and complete remission rate was 46%. The incidence rates of cytokine-release syndrome and neurotoxicity (grade ≥ 3) were 9 and 5%, respectively. The various clinical factors were analyzed. Autogenic CAR-T cell may lead to improved efficacy than allogeneic CAR-T cell. CD20 CAR-T cell may show increased efficacy than CD19 CAR-T cell. CAR-T immunotherapy has remarkable efficacy and low toxicity in relapsed/refractory B-NHL.
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| http://dx.doi.org/10.2217/imt-2020-0221 | DOI Listing |
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