AI Article Synopsis
- Genetically identical female honeybee larvae can become either sterile workers or fertile queens based on their diet, and differences in RNA N-methyladenosine (mA) methylation may influence this process.
- Research shows that the mA methylome changes during the larvae's growth and is linked to feeding differences, with worker larvae having more hypermethylated mA marks than queen larvae.
- Suppressing mA methylation in worker larvae allows them to develop characteristics of queens, indicating that mA plays a significant role in caste differentiation, but other factors might also be involved.
Article Abstract
Genetically identical female honeybee larvae with different diets develop into sterile workers or fertile queens. It remains unknown whether the reversible RNA N-methyladenosine (mA) mark functionally impact this "caste differentiation." Here, we profile the transcriptome-wide mA methylome of honeybee queen and worker larvae at three instar stages and discover that mA methylation dynamics are altered by differential feeding. Multiple methylome comparisons show an obvious increase in mA marks during larval development and reveal a negative correlation between gene expression and mA methylation. Notably, we find that worker larvae contain more hypermethylated mA peaks than do queen larvae, and many caste-differentiation-related transcripts are differentially methylated. Chemical suppression of mA methylation in worker larvae by 3-deazaadenosine (DAA) reduces overall mA methylation levels and triggers worker larvae to develop queen caste features. Thus, our study demonstrates that mA functionally impacts caste differentiation and larval development, yet it does not exclude potential contributions from other factors.
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| http://dx.doi.org/10.1016/j.celrep.2020.108580 | DOI Listing |
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