AI Article Synopsis
- Two boys, aged 23 months and 6 years, were found to have pediatric lung cancer due to tumors transmitted from their mothers during pregnancy.
- The first child showed spontaneous regression of some tumors, while the second experienced slow tumor growth, indicating possible immune responses to the transmitted cancer.
- Treatment with nivolumab, an immune checkpoint inhibitor, resulted in significant tumor regression in the first child, highlighting a promising approach for this rare cancer transmission.
Article Abstract
Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses against the transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong regression of all remaining tumors in the first child. (Funded by the Japan Agency for Medical Research and Development and others; TOP-GEAR UMIN Clinical Trials Registry number, UMIN000011141.).
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| http://dx.doi.org/10.1056/NEJMoa2030391 | DOI Listing |
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