PEGylation (i.e., attachment of polyethylene-glycol) of carbon nanotubes (CNTs) is one of the most widely used strategies to improve its biocompatibility and aqueous dispersion stability, which are critical for their successful clinical application. However, PEGylation of nanomaterials has recently been associated with production of anti-PEG antibody, low cellular uptake, and degradation. Herein, we explore surface functionalization of CNTs using the bovine-milk-derived protein succinylated β-lactoglobuline (Sblg) as an alternative strategy to PEGylation. The aqueous dispersion stability, in vitro cell uptake and biocompatibility of Sblg-functionalized multiwalled CNTs (Sblg-f-MWCNTs) was compared to PEGylated MWCNTs (PEG-f-MWCNTs). The surface functionalization with Sblg was found to improve the IC50 values of CNTs by ∼5- to 6-fold in comparison with pristine CNTs in various cell lines. Both Sblg-f-MWCNTs and PEG-f-MWCNTs improved the aqueous colloidal stability of CNTs, which remained suspended for a period of one month. Our study concluded that the Sblg provides a cost-effective alternative to the PEG-based CNT functionalization with significant improvement in the biocompatibility and dispersion stability of CNTs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsbiomaterials.9b00268 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth-Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties.
Cell Biochem Funct
February 2025
Department of Life Sciences, Hemchandracharya North Gujarat University, Patan, India.
The present study aimed to optimize a mouth-dissolving film (MDF) made from Pongamia pinnata stem bark extract to increase patient compliance and accelerate oral disease therapy. Several stem bark extracts were prepared, and karanjin was used as an herbal marker for the extracts. The ethanolic extract showed the maximum yield (12.
View Article and Find Full Text PDFState-of-the-art laser frequency stabilization is limited by miniscule length changes caused by thermal noise. In this work, a cavity-length-insensitive frequency stabilization scheme is implemented using strong dispersion in a 21 mm long cavity with a europium-ion-doped spacer of yttrium orthosilicate. A number of limiting factors for slow light laser stabilization are evaluated, including the inhomogeneous and homogeneous linewidth of the ions, the deterioration of spectral windows, and the linewidth of the cavity modes.
View Article and Find Full Text PDFSapphire fiber Bragg gratings (SFBGs) are promising high-temperature sensors in many harsh environments, such as aviation, nuclear power, and furnaces. Here, we proposed and experimentally demonstrated a quasi-distributed high-temperature sensor based on an SFBG array sealed in an argon gas-infiltrated sapphire tube interrogated by using an InGaAs-based interrogator. An SFBG array including five SFBGs was inscribed using the femtosecond laser line-by-line method and sealed in an argon gas-infiltrated sapphire tube.
View Article and Find Full Text PDFThe detection of lead ions (Pb) is crucial due to its harmful effects on health and the environment. In this article, what we believe to be a novel dielectric-metal hybrid structure localized surface plasmon resonance (LSPR) sensor for ultra-trace detection of Pb is proposed, featuring a zinc sulfide layer, silver nanodisks (Ag-disks), and graphene oxide (GO) covering the Ag-disks. The sensor works by detecting the variation of gold nanoparticles (AuNPs) on its surface when Pb cleaves a substrate strand linked to a DNAzyme, causing the AuNPs modified on the substrate strand to disperse.
View Article and Find Full Text PDFRecently, the dissipative soliton (DS) generation in the positive fourth-order-dispersion (FOD) fiber laser has been theoretically predicted, namely dissipative pure-quartic soliton (DPQS), featuring a higher energy-scaling ability compared to conventional DS dominated by positive group velocity dispersion. Here, we discover that the formation of spectral sidebands is always accompanying by the stabilized DPQS in the fiber laser, which is different from the conventional DS. Due to the combination of positive FOD and self-phase modulation, low- and high-frequency components are distributed at the leading and trailing edges of the pulse, forming the pedestals that propagate with it.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!