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Immune checkpoint inhibitors-associated vasculitis: a heterogeneous condition with possible severe disease course.
Rheumatology (Oxford)
December 2024
AP-HP, Université Paris Saclay, department of internal medicine and clinical immunology, Bicêtre Hospital, Le Kremlin Bicêtre, France.
Objective: To describe presentation, treatment and outcome of immune checkpoint inhibitor (ICI) associated-vasculitis in cancer patients in a multicentre study.
Methods: Thanks to the ImmunoCancer International Registry (ICIR), a multidisciplinary network focused on the research of the immune related adverse events related to cancer immunotherapies, patients presenting with a clinical and/or radiological suspicion of vasculitis, and histological evidence of vasculitis after being exposed to ICIs were retrospectively identified.
Results: Twenty eight cases were identified in the ICIR registry.
Successful treatment of cutaneous polyarteritis nodosa with baricitinib.
J Dermatolog Treat
December 2024
Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis preferentially targeting medium-sized arteries. PAN has two clinical entities: systemic PAN (sPAN) and cutaneous PAN (cPAN). cPAN is a skin-limited vasculitis, while ulcerative cPAN often predicts a higher risk of recurrence and a worse prognosis.
View Article and Find Full Text PDFAcute digital ischemia due to lupus vasculitis successfully treated with anifrolumab.
Int J Dermatol
October 2024
Department of Rheumatology, University of Yamanashi Hospital, Chuo-shi, Yamanashi, Japan.
Vasculitis associated with VEXAS syndrome.
Rheumatology (Oxford)
October 2024
Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- The study aimed to assess the prevalence and characteristics of vasculitis in patients diagnosed with VEXAS syndrome, confirmed through UBA1 mutation.
- A total of 89 male patients with an average age of nearly 67 years were evaluated, with 23.6% showing signs of vasculitis, predominantly small vessel types.
- Findings suggest that VEXAS syndrome can present with vasculitis-related symptoms, including cranial issues that may resemble other conditions like giant cell arteritis, though significant large vessel involvement is infrequent.
A case of anti-CD320 antibody-positive cutaneous arteritis accompanied by multiple cranial nerve symptoms.
Rheumatology (Oxford)
September 2024
Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
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