This study aimed to investigate the factors that are independently associated with hepcidin-25 and its relationship with doses of erythropoiesis-stimulating agents (ESAs) and intravenous iron in stable maintenance hemodialysis patients (smHD) stratified by ESAs administration. In 103 adult smHD (ESAs therapy (N = 64) and ESAs-free (N = 39)), median values of biologically active hepcidin-25 (chemiluminescent direct ELISA assay) and ferritin levels were significantly higher whereas red blood cell count, hemoglobin, and hematocrit values were lower in ESAs therapy compared to ESAs-free group (P < .001, for all). Our results suggest that ESAs-independent smHD exhibit supposedly normal hepcidin-25 levels and preserved iron homeostasis, with a lower degree of anemia. The results of our multivariable model indicate that hepcidin-25 levels are independently and positively associated with iron stores and inflammation, and inversely with active erythropoiesis, regardless of ESAs administration. Maintenance ESAs and the intravenous iron dose were not related to hepcidin-25 levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1744-9987.13617 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Serum hepcidin evaluation as a promising biomarker in juvenile idiopathic arthritis.
Clin Exp Rheumatol
August 2024
Department of Paediatrics, G. D'Annunzio University, Chieti, Italy.
Objectives: An important area of research in juvenile idiopathic arthritis (JIA) aims to identify sensitive and reliable biomarkers of disease activity. The key iron-regulatory hormone hepcidin-25 (HEP) has been advocated as a potential biomarker to assess anaemia of chronic disease and iron deficiency in adults with rheumatoid arthritis.
Methods: We performed a cross-sectional study evaluating the utility of serum HEP in 79 non-systemic onset JIA patients (14 males, 65 females), with/without anaemia, determining its correlations with disease activity, assessed by the JIA Disease Activity Score (JADAS)-27, anaemia parameters, and iron status indices.
Evaluation of hepcidin-25/erythroferrone ratio as a potential biomarker for iron utility and erythropoiesis responsiveness to erythropoiesis-stimulating therapy in comparison to immature erythrocyte/reticulocyte parameters in hemodialysis patients.
Hematol Transfus Cell Ther
November 2024
Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Background: Anemia-associated chronic kidney disease increases in more advanced stages with a subsequent acceleration in renal impairment progressing to end-stage renal disease. Although hepcidin and erythroferrone have been described as novel biomarkers of iron metabolism, there is still an area of ambiguity regarding iron utility in anemia-associated end-stage renal disease.
Objectives: This study aims to determine the correlations between erythropoietin, erythroferrone, and hepcidin-25 in hemodialysis, and to evaluate the clinical utility of the hepcidin-25/erythroferrone ratio as a biomarker of erythropoiesis-stimulating agent effectiveness compared to reticulocyte maturation parameters.
Continuous training in young athletes decreases hepcidin secretion and is positively correlated with serum 25(OH)D and ferritin.
PeerJ
July 2024
Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Background: Iron deficiency is known to impair muscle function and reduce athletic performance, while vitamin D has been reported to induce iron deficiency. However, the mechanism underlying exercise-induced changes in iron metabolism and the involvement of vitamins in this mechanism are unclear. The present study examined changes in biological iron metabolism induced by continuous training and the effects of vitamin D on these changes.
View Article and Find Full Text PDFNovel mutation of transferrin receptor 2 causing hereditary hemochromatosis type 3 in a Japanese patient.
Hepatol Res
June 2024
Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Article Synopsis
- Hereditary hemochromatosis (HH) is a serious iron-storage disorder that can cause significant organ damage, and HH type 3 is linked to mutations in the TFR2 gene, which is rare in Asia.
- A 69-year-old Japanese woman with joint pain and liver issues was found to have high iron levels and a novel homozygous mutation in her TFR2 gene, identified through genetic testing.
- After treatment with phlebotomy, her arthritis and liver enzyme levels improved, marking the first documented case of this specific mutation in an HH type 3 patient.
The relationship between asymptomatic atherosclerosis and hepcidin-25 in chronic kidney disease patients.
Ann Saudi Med
November 2023
From the Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt.
Background: The most common and lethal consequence of chronic kidney disease (CKD) is atherosclerotic cardiovascular disease. The persistent inflammation present in CKD increases hepcidin levels. Iron accumulates in the arterial wall in atherosclerosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!