Background: Induction of labour (IOL) is an obstetric procedure that should be conducted in a healthcare facility with the capacity to provide optimal care based on the patient risk status. Inadequate monitoring, untimely procedure and lack of readily available and experienced medical staff to participate in the care of the patient undergoing induction are hazardous with snowball effects.
Methods: A 38-year-old G4P2+1 had IOL because of oligohydramnios at term in a district hospital. The procedure was inadequately monitored and fetal demise occurred. The duration of second stage was prolonged and sequential use of vacuum and forceps deliveries were unsuccessfully performed.
Results: At the ensuing caesarean delivery, uterine rupture/tear was diagnosed, and the patient died due to haemorrhage during an emergency hysterectomy.
Conclusion: This report highlights important clinical lessons on IOL in a high-risk pregnancy. The timelines for monitoring during IOL, particularly when there is fetal demise in labour, are proposed.
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http://dx.doi.org/10.4314/ahs.v20i3.27 | DOI Listing |
Int J Gynaecol Obstet
March 2025
Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israel.
Objective: We studied whether Doppler flow measurements before initiation of induction of labor (IOL) can predict non-reassuring fetal heart rate (NRFHR) monitoring in women at 38-41 weeks of gestation.
Materials And Methods: We performed a prospective observational study in a single tertiary medical center between November 2017 and December 2019. Women undergoing induction of labor were included.
Drug Metab Dispos
February 2025
Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc, Groton, Connecticut.
Quantifying proteins involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs is essential to improve understanding of their disposition and pharmacokinetics. Proteomics, because of its great versatility, is a widely used approach for protein analysis. However, existing protocols face challenges, such as poor peptide identification in liquid chromatography with tandem mass spectrometry under multiple reaction monitoring mode as well as the time- and labor-intensive nature of detergent-engaged workflows.
View Article and Find Full Text PDFJ Craniovertebr Junction Spine
January 2025
Division of Neurosurgery, Mountainside Medical Center, Hackensack Meridian School of Medicine, Montclair, New Jersey.
Pregnancy-induced changes to spinal anatomy and physiology can increase the complexity of neurosurgical intervention in this population. There are numerous reports focused on the neurosurgical management of intracranial pathology for pregnant patients. However, less is known about the neurosurgical management of acute spinal pathology.
View Article and Find Full Text PDFIntroduction: Survival in cystic fibrosis (CF) is increasing and more women are considering their reproductive options, however there is limited data on pregnancy and neonatal outcomes in this population. The objectives of this study were to describe maternal and neonatal outcomes in women with CF and the general Canadian maternal population (general population).
Methods: Maternal and neonatal clinical outcomes and healthcare utilization for in-hospital live births was retrieved from the Canadian Institute for Health Information's Discharge Abstract Database.
Sci Rep
March 2025
Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
The capacity to forecast nonreassuring fetal heart (NFH) is essential for minimizing perinatal complications; therefore, this research aims to establish if a machine learning (ML) model can predict NFH. This was a retrospective analysis of information gathered from singleton cases over the gestational age of 28 weeks that sought vaginal delivery between January 2020 and January 2022. The information was acquired from the "Iranian Maternal and Neonatal Network.
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