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| http://dx.doi.org/10.1177/0253717620936985 | DOI Listing |
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A prospective study of acute propranolol overdose defining dose thresholds of severe toxicity (ATOM - 9).
Clin Toxicol (Phila)
January 2025
Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia.
Introduction: Propranolol is a beta-adrenoceptor blocking drug with sodium channel-blocking properties that can cause life-threatening toxicity in overdose. Limited research defines dose thresholds of toxicity. We aimed to investigate propranolol overdose and dose thresholds for severe toxicity.
View Article and Find Full Text PDFEvolving trends of pharmaceutical poisonings associated with QRS complex prolongation.
Clin Toxicol (Phila)
September 2024
American College of Medical Toxicology, Phoenix, AZ, USA.
Introduction: Tricyclic antidepressants often cause drug-induced QRS complex prolongation in overdose but are now less commonly prescribed. We sought to determine, among a contemporary cohort of patients, the pharmaceuticals independently associated with QRS complex prolongation in acute overdose.
Methods: We performed secondary analysis of data from the Toxicology Investigators Consortium (ToxIC) Core Registry.
Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model.
Sci Rep
June 2024
Department of Psychiatry, Indiana University School of Medicine, 320 W. 15th Street, NB 300E, Indianapolis, IN, 46202, USA.
Binge drinking (BD) contributes strongly to the harms of alcohol use disorder. Most rodent models do not result in binge-level blood alcohol concentrations (BACs), and to better understand individual and sex differences in neurobiological mechanisms related to BD, the use of outbred rat strains would be valuable. Here, we developed a novel BD model where after 3+ months of intermittent access to 20% alcohol Wistar rats drank, twice a week, with two 5-min intake (what we called Two-shot) separated by a 10-min break.
View Article and Find Full Text PDFExcessively High Chronic Propranolol Overdose in Infantile Hemangioma: A Case Report.
Am J Case Rep
November 2023
Corporate Department of Pharmacy Services, King Saud University Medical City, Riyadh, Saudi Arabia.
Article Synopsis
- Infantile hemangiomas are common childhood tumors, affecting about 5% of infants, with propranolol as the recommended treatment.
- A 7-month-old girl accidentally received a dose of propranolol that was eight times the recommended amount but showed no symptoms or abnormalities in tests.
- The overdose was managed by tapering the medication gradually, and after 6 weeks on a therapeutic dose, the hemangioma began to fade, highlighting the importance of careful monitoring during treatment.
Hemolacria secondary to major depressive disorder and generalized anxiety disorder: A case report.
Clin Case Rep
November 2023
Neurosurgery Department Namazi Hospital, Shiraz University of Medical Sciences Shiraz Iran.
Key Clinical Message: Hemolacria can occur on the basis of a psychiatric disorder without an organic cause. However, this should be a diagnosis of exclusion. Treatment of the underlying psychiatric illness may relieve this condition.
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