Increased F-FDG accumulation in less-affected lung area in patients with non-small cell lung cancer and postoperative acute exacerbation of interstitial lung disease.

Purpose: To investigate whether or not F-FDG accumulation in normal or less-affected lung fields increased in non-small cell lung cancer (NSCLC) patients with postoperative acute exacerbation (PAE) of interstitial lung disease (ILD) MATERIAL AND METHODS: Thirty-six NSCLC patients with ILD and 50 patients without ILD (non-ILD patients) underwent pre-operative F-FDG-PET/CT at 2 institutions. Volume-of-interest (VOI) was placed to measure the mean standardized uptake value (SUV) in normal or less-affected lung fields at pre-defined 12 areas on ventral and dorsal locations of both lungs. SUV was defined as corrected SUV by using TF and mean computed tomography density on PET/CT. Harmonized SUV (hSUV) and SUV (hSUV) were calculated based on results of phantom study, which was performed to optimize the measured SUV difference among 2 institutions. Both the h-SUV and the h-SUV were compared between 8 patients with PAE of ILD (PAE group) or remaining 28 patients without PAE of ILD (non-PAE group) and non-ILD patients in each of the 12 areas.

Results: The hSUV in PAE group was higher in 9 out of 12 locations as compared with non-ILD patients, whereas the hSUV was mostly similar between non-PAE group and non-ILD patients. In contrast, the hSUV in non-PAE group was similar to that in PAE group, and higher than in non-ILD patients in most locations.

Conclusion: F-FDG-PET/CT demonstrated increased SUV along with elevated SUV in normal or less-affected lung fields for NSCLC patients with PAE of ILD, which may reflect regional invisible fibrosis and inflammatory change.