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Rh(III)-Catalyzed three-component cascade annulation to produce the -oxopropyl chain of isoquinolone derivatives. | LitMetric
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Rh(III)-Catalyzed three-component cascade annulation to produce the -oxopropyl chain of isoquinolone derivatives.

Yuan He Xian-Zhang Liao Lin Dong Fen-Er Chen

Org Biomol Chem

Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. and Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China and Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.

Published: January 2021

Developing powerful methods to introduce versatile functional groups at the N-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct the N-oxopropyl chain of isoquinolone derivatives via rhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.

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 Source
http://dx.doi.org/10.1039/d0ob02389bDOI Listing

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