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| http://dx.doi.org/10.1363/psrh.12170 | DOI Listing |
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Examining the Impact of Diet-and-Exercise-Induced Weight Loss on Drug Metabolism and Gastric Emptying in Patients with Obesity.
J Clin Pharmacol
January 2025
Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Obesity significantly influences drug pharmacokinetics (PK), which challenges optimal dosing. This study examines the effects of diet-and-exercise-induced weight loss on key drug-metabolizing enzymes and gastric emptying in patients with obesity, who frequently require medications for comorbidities. Participants followed a structured weight management program promoting weight loss over 3-6 months and were not concomitantly on potential CYP inducers or inhibitors.
View Article and Find Full Text PDFControlled-release nitrogen combined with ordinary nitrogen fertilizer improved nitrogen uptake and productivity of winter wheat.
Front Plant Sci
January 2025
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Agronomy, Northwest A & F University, Yangling, Shaanxi, China.
Background: Blending controlled-release nitrogen fertilizer (CRNF) with ordinary nitrogen fertilizer (ONF) is a strategic approach to improve winter wheat nutrient management. This blend provides nitrogen (N) to winter wheat in a balanced and consistent manner, ensuring long-term growth, reducing nutrient loss due to leaching or volatilization, and increasing N use efficiency (NUE).
Aims: CRNF aims to enhance N application suitability, optimizes soil nutrient dynamics, and its widespread use can boost crop NUE and yield.
Discovering non-associated pressure-sensitive plasticity models with EUCLID.
Adv Model Simul Eng Sci
January 2025
Department of Mechanical and Process Engineering, Institute for Mechanical Systems, ETH Zürich, Zürich, 8092 Switzerland.
We extend (EUCLID Efficient Unsupervised Constitutive Law Identification and Discovery)-a data-driven framework for automated material model discovery-to pressure-sensitive plasticity models, encompassing arbitrarily shaped yield surfaces with convexity constraints and non-associated flow rules. The method only requires full-field displacement and boundary force data from one single experiment and delivers constitutive laws as interpretable mathematical expressions. We construct a material model library for pressure-sensitive plasticity models with non-associated flow rules in four steps: (1) a Fourier series describes an arbitrary yield surface shape in the deviatoric stress plane; (2) a pressure-sensitive term in the yield function defines the shape of the shear failure surface and determines plastic deformation under tension; (3) a compression cap term determines plastic deformation under compression; (4) a non-associated flow rule may be adopted to avoid the excessive dilatancy induced by plastic deformations.
View Article and Find Full Text PDFMicroalgae: An Exciting Alternative Protein Source and Nutraceutical for the Poultry Sector.
Food Sci Anim Resour
January 2025
Department of Human Anatomy, Medical College of Qinghai University, Xining 810016, China.
Microalgae have garnered a considerable attention as a sustainable substitute as customary feed ingredients for poultry, predominantly due to their extraordinary nutritive profile and purposeful properties. These minuscule organisms are protein rich, retain an ample quantity of essential fatty acids, vitamins, minerals, and antioxidants, thus are capable of improving nutritive value of poultry diets. Microalgae comparatively delivers an outstanding source of protein containing substantial amount of innumerable bioactive complexes, omega-3 fatty acids in addition to the essential amino acids (methionine and lysine), crucial for optimal growth and development.
View Article and Find Full Text PDFC-X-C chemokine receptor type 5CD8 T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferon-alpha treatment.
World J Gastroenterol
January 2025
Institute of Hepatology and Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Background: C-X-C chemokine receptor type 5 (CXCR5)CD8 T cells represent a unique immune subset with dual roles, functioning as cytotoxic cells in persistent viral infections while promoting B cell responses. Despite their importance, the specific role of CXCR5CD8 T cells in chronic hepatitis B (CHB), particularly during interferon-alpha (IFN-α) treatment, is not fully understood. This study aims to elucidate the relationship between CXCR5CD8 T cells and sustained serologic response (SR) in patients undergoing 48 weeks of pegylated IFN-α (peg-IFN-α) treatment for CHB.
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