Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/abbs/gmaa172 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Toxicity assessment of titanium dioxide nanoparticles on microorganisms through topological data analysis of high dimensional single-cell nanomechanical data.
Talanta
December 2024
Université de Lorraine, CNRS, LIEC, F-54000, Nancy, France.
There is a growing interest in the development of methods for the detection of nanoparticle (NP) toxicity to living organisms based on the analysis of relevant multidimensional data sets. In particular the detection of preliminary signs of NPs toxicity effects would benefit from the selection of data featuring NPs-induced alterations of biological barriers. Accordingly, we present an original Topological Data Analysis (TDA) of the nanomechanical properties of Escherichia coli cell surface, evaluated by multiparametric Atomic Force Microscopy (AFM) after exposure of the cells to increasing concentrations of titanium dioxide nanoparticles (TiONPs).
View Article and Find Full Text PDFSubstrate stiffness modulates extracellular vesicles' release in a triple-negative breast cancer model.
Extracell Vesicles Circ Nucl Acids
September 2024
Nano-Innovation Laboratory, Elettra-Sincrotrone Trieste S.C.p.A., Trieste 34149, Italy.
Aim: The microenvironment effect on the tumoral-derived Extracellular Vesicle release, which is of significant interest for biomedical applications, still represents a rather unexplored field. The aim of the present work is to investigate the interrelation between extracellular matrix (ECM) stiffness and the release of small EVs from cancer cells. Here, we focus on the interrelation between the ECM and small extracellular vesicles (sEVs), specifically investigating the unexplored aspect of the influence of ECM stiffness on the release of sEVs.
View Article and Find Full Text PDFDengue (DENV) and Zika virus (ZIKV), transmitted by Aedes mosquitoes, pose significant public health challenges. Effective treatments for these viruses remain elusive, highlighting the urgent need for new efficient antiviral therapies. This study explores prodigiosin, a microbial tripyrrole pigment, as an antiviral agent against both DENV and ZIKV employing advanced analytical approaches which integrate molecular docking, CASTp 3.
View Article and Find Full Text PDFEarly and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation.
Cell Mol Biol Lett
November 2024
Institute of Nuclear Physics Polish Academy of Sciences, 31342, Krakow, Poland.
Background: Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called fenestrations, participating in the bidirectional transport between the vascular system and liver parenchyma. Fenestrated LSECs indicate a healthy phenotype of liver while loss of fenestrations (defenestration) in LSECs is associated with liver pathologies.
Methods: We introduce a unique model of systemic inflammation triggered by the deletion of Mcpip1 in myeloid leukocytes (Mcpip1LysM) characterised by progressive alterations in LSEC phenotype.
G-PCC-FISH derived multi-parametric biodosimetry methodology for accidental high dose and partial body exposures.
Sci Rep
July 2024
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
High dose radiation exposures are rare. However, medical management of such incidents is crucial due to mortality and tissue injury risks. Rapid radiation biodosimetry of high dose accidental exposures is highly challenging, considering that they usually involve non uniform fields leading to partial body exposures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!