Illihenin A (), a novel sesquiterpenoid, was isolated from the roots of . The structure was determined by spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction. Compound represents a class of novel 5/7/6 tricyclic sesquiterpenoids featuring a rare cage-like tricyclo[6.2.2.0]dodecane core. A plausible biosynthetic pathway of by rearrangement of -cedrane is proposed. Additionally, showed potent antiviral activity against coxsackievirus B3 with an IC value of 2.87 μM.
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| http://dx.doi.org/10.1021/acs.joc.0c02727 | DOI Listing |
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