AI Article Synopsis
- Head and neck cancer (HNC) is a common type of cancer that affects the upper aerodigestive tract and has a low 5-year survival rate of 40-50% due to late diagnosis and recurrence.
- Recent research has uncovered non-coding RNAs (like microRNAs and long non-coding RNAs) in the blood and saliva of HNC patients, suggesting they might be useful for early detection and diagnosis.
- The review discusses how analyzing these circulating non-coding RNAs could significantly improve clinical decision-making and management of HNC.
Article Abstract
Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and recurrence. Recently, non-coding RNAs, including tRNA halves, YRNA fragments, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs), have been identified in the blood and saliva of patients diagnosed with HNC. These observations have recently fueled the study of their potential use in early detection, diagnosis, and risk assessment. The present review focuses on recent insights and the potential impact that circulating non-coding RNA evaluation may have on clinical decision-making in the management of HNC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823329 | PMC |
| http://dx.doi.org/10.3390/cells10010048 | DOI Listing |
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