AI Article Synopsis
- * Recent findings highlight GnRH agonist as a viable option for triggering ovulation, offering benefits such as a more personalized treatment approach and reduced need for prolonged progesterone therapy.
- * The best strategy involves using the GnRH agonist in conjunction with a 'freeze all' policy to minimize the risk of ovarian hyperstimulation syndrome (OHSS), while discussing methods for supporting the corpus luteum if fresh embryo transfers are pursued.
Article Abstract
Purpose Of Review: In a conventional IVF cycle, final oocyte maturation and ovulation is triggered with a bolus of hCG, followed by progesterone-based luteal support that spans several weeks if pregnancy is achieved. This article summarizes several approaches of the exogenous progesterone-free luteal support in IVF.
Recent Findings: Triggering ovulation with GnRH agonist may serve as an alternative to hCG, with well established advantages. In addition, the luteal phase can be individualized in order to achieve a more physiologic hormonal milieu, and a more patient friendly treatment, alleviating the burden of a lengthy exogenous progesterone therapy.
Summary: GnRH agonist trigger followed by a 'freeze all' policy is undoubtedly the best approach towards the 'OHSS-free clinic'. If fresh embryo transfer is considered well tolerated after GnRH agonist trigger, rescue of the corpora lutea by LH activity supplementation is mandatory. Herein we discuss the different approaches of corpus luteum rescue.
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| http://dx.doi.org/10.1097/GCO.0000000000000682 | DOI Listing |
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