AI Article Synopsis
- Mullerian adenosarcoma is a rare type of malignant uterine tumor characterized by both benign and malignant cells, and it can follow a history of pelvic irradiation.
- The case discussed involves a 45-year-old woman who experienced post-menopausal bleeding and had a history of cervical cancer treatment, later diagnosed with adenosarcoma showing malignant features.
- The patient faced a recurrence of the cancer three months later and ultimately passed away, emphasizing the need for further understanding of the relationship between radiation therapy and the development of such tumors.
Article Abstract
Mullerian adenosarcoma is an uncommon biphasic malignant uterine tumor. It is composed of benign epithelial and malignant stromal elements. We present a case of a 45-year-old woman who presented with post-menopausal bleeding for three months. She had a significant past medical history of pelvic irradiation for squamous carcinoma of cervix 20 years ago. Pathology revealed adenosarcoma with sarcomatous overgrowth. The patient had a recurrence of pure sarcoma three months later and unfortunately succumbed to her disease. The role of radiation in the pathogenesis of adenosarcoma has been uncommonly described compared to its well established role in the development of carcinosarcoma. Our case fulfils the criteria for a radiation induced sarcoma. We review the salient clinical and pathological features of this uncommon lesion highlighting the importance of sarcomatous overgrowth in these lesions and the possible role of radiation in the development of these tumors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183353 | PMC |
| http://dx.doi.org/10.32074/1591-951X-114 | DOI Listing |
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