The fifth biennial ORS PSRS International Spine Research Symposium took place from November 3 to 7, 2019, at Skytop Lodge in northeastern Pennsylvania. Organized jointly by the Orthopaedic Research Society and the Philadelphia Spine Research Society, the symposium attracted more than 180 participants from 10 different countries to share the latest advances in basic and preclinical spine research. Following the symposium, participants were invited to submit full-length manuscripts to this special issue of JOR Spine.

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